Expression of syndecan-1 and E-cadherin is inversely correlated with poor patient's prognosis and recurrent status of extrahepatic bile duct carcinoma
Expression of syndecan-1 and E-cadherin is inversely correlated with poor patient's prognosis and recurrent status of extrahepatic bile duct carcinoma
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DOI：
10.2220/biomedres.30.79
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发表时间：
2009-04-01
影响因子：
1.2
通讯作者：
Kijima, Hiroshi
中科院分区：
文献类型：
--
作者：
Ohashi, Motonari;Kusumi, Tomomi;Kijima, Hiroshi
肝外胆管癌是最具侵袭性的癌症之一，治愈性切除后预后较差。 Syndecan-1 和 E-cadherin 是跨膜糖蛋白，在细胞间粘附和肿瘤进展中具有重要作用。在这项研究中，我们检查了 84 例手术切除的肝外胆管腺癌病例，以阐明 syndecan-1/E-cadherin 表达的临床病理意义。 69.0%（58/84）和46.4%（39/84）的胆管癌中syndecan-1和E-cadherin表达减少。 syndecan-1 表达减少与淋巴/静脉/神经侵犯相关 (P < 0.0001)，并且与较短的总生存期相关 (P = 0.0002)。 E-钙粘蛋白表达减少与淋巴和神经侵袭相关（分别为P = 0.008，P < 0.0001），并且与总生存期短相关（P = 0.0038）。结果表明，syndecan-1/E-cadherin 表达降低可能是肝外胆管癌复发和预后的良好指标。
Extrahepatic bile duct carcinoma is one of the most extremely aggressive cancers with poor prognosis after curative resection. Syndecan-1 and E-cadherin are transmembrane glycoproteins, and have important roles in cell-cell adhesion and tumor progression. In this study, we examined 84 surgically resected cases of extrahepatic bile duct adenocarcinoma to clarify clinicopathological significance of syndecan-1/E-cadherin expression. Reduced expressions of syndecan-1 and E-cadherin were found in 69.0% (58/84) and 46.4% (39/84) of the bile duct carcinomas. Reduced syndecan-1 expression was correlated with lymphatic/venous/nervous invasion (P < 0.0001), and was associated with short overall survival (P = 0.0002). Reduced E-cadherin expression was correlated with lymphatic and nervous invasion (P = 0.008, P < 0.0001, respectively), and was associated with short overall survival (P = 0.0038). The results indicated that reduced syndecan-1/E-cadherin expression may be good indicators of recurrence and prognosis in extrahepatic bile duct carcinoma.