HEAVY-METAL CHELATORS PROLONG MOTILITY AND VIABILITY OF SEA-URCHIN SPERM BY INHIBITING SPONTANEOUS ACROSOME REACTIONS
HEAVY-METAL CHELATORS PROLONG MOTILITY AND VIABILITY OF SEA-URCHIN SPERM BY INHIBITING SPONTANEOUS ACROSOME REACTIONS
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DOI：
10.1002/jez.1402260314
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发表时间：
1983-01-01
影响因子：
--
通讯作者：
EPEL, D
中科院分区：
文献类型：
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作者：
JOHNSON, CH;EPEL, D
已知多种重金属螯合剂[氨基酸、EDTA和二乙基二硫代氨基甲酸盐]可延长海胆[Lytechinus pictus]精子的活力和活动能力。这些药物通过防止精子在海水中稀释后自发发生的顶体反应来维持精子的能力。这些螯合剂还抑制由高pH或卵冻诱导的顶体反应。由于顶体反应的诱导导致废除运动性的步骤，特别是大量的Ca2+摄取和伴随的细胞质酸化，运动性被这些螯合剂延长。重金属可能在控制海胆精子顶体反应中起作用。
A variety of heavy metal chelating agents [amino acids, EDTA and diethyldithiocarbamate] is known to prolong the fertilizing capacity and motility of sea urchin [Lytechinus pictus] sperm. These agents maintain fertilizing capacity by preventing acrosome reactions which occur spontaneously after dilution of sperm into seawater. These chelating agents also inhibit acrosome reactions induced by high pH or egg jelly. Since induction of the acrosome reaction leads to steps that abolish motility, specifically a massive Ca2+ uptake and concomitant acidification of the cytoplasm, motility is prolonged by these chelators. Heavy metals may play a role in controlling the acrosome reaction in sea urchin sperm.