A GENE AFFECTING THE SPECIFICITY OF THE CHEMOSENSORY NEURONS OF DROSOPHILA
A GENE AFFECTING THE SPECIFICITY OF THE CHEMOSENSORY NEURONS OF DROSOPHILA
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DOI：
10.1038/330062a0
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发表时间：
1987-11-05
期刊：
影响因子：
64.8
通讯作者：
SIDDIQI, O
中科院分区：
文献类型：
--
作者：
ARORA, K;RODRIGUES, V;SIDDIQI, O
果蝇的喙和跗骨上的感受器包括五个神经元，四个化学感受器和一个机械感受器1 -3。指定为S的糖敏感神经元携带吡喃糖、呋喃糖和海藻糖的独立受体位点4 -7。另外两个，L1和L2，对盐有反应。第四个神经元W被盐和糖抑制，并且被认为介导水的检测。我们在这里描述了一个基因，其中突变改变了神经元的方式，S细胞是兴奋的盐。因此，突变苍蝇强烈吸引NaCl的浓度是排斥野生型。据我们所知，这是第一个改变化学感受神经元特异性的突变。
The sensilla on the proboscis and tarsi ofDrosophilacontain five neurons, four chemosensory and one mechanosensory1–3. The sugar-sensitive neuron, designated S, carries independent acceptor sites for pyranose, furanose and trehalose4–7. Two others, L1 and L2, respond to salts2. The fourth neuron, W, is inhibited by salts and sugars, and is believed to mediate detection of water. We describe here a gene in which mutations alter the neurons in such a way that the S cell is excited by salts. As a result, the mutant flies are strongly attracted by NaCl at concentrations which are repellent to the wild type. To our knowledge, this is the first instance of a mutation which changes the specificity of the chemosensory neurons.