Renal distribution of Vasohibin-1 in patients with chronic kidney disease.
Renal distribution of Vasohibin-1 in patients with chronic kidney disease.
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DOI：
10.18926/amo/52788
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发表时间：
2014-06
影响因子：
0.5
通讯作者：
Norikazu Hinamoto;Y. Maeshima;D. Saito;H. Yamasaki;Katsuyuki Tanabe;Tatsuyo Nasu;H. Watatani;H. Ujike;M. Kinomura;H. Sugiyama;H. Sonoda;N. Kanomata;Yasufumi Sato;H. Makino
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文献类型：
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作者：
Norikazu Hinamoto;Y. Maeshima;D. Saito;H. Yamasaki;Katsuyuki Tanabe;Tatsuyo Nasu;H. Watatani;H. Ujike;M. Kinomura;H. Sugiyama;H. Sonoda;N. Kanomata;Yasufumi Sato;H. Makino
实验研究已经证明血管生成相关因子参与慢性肾脏疾病（CKD）的进展。血管生成负反馈调节因子Vasohibin-1（VASH-1）在CKD中的分布及临床作用尚未见报道。我们招募了54名日本CKD患者和6名因局限性肾细胞癌切除正常肾组织的患者。我们评估了肾脏VASH-1表达水平与临床/组织学参数之间的相关性。VASH-1在肾内皮/系膜细胞、新月体病变和间质炎性细胞中观察到。新月体形成与肾小球内VASH-1+细胞数呈显著正相关（r = 0.48，p = 0.001）或皮质（r = 0.64，p <0.0001），2）皮质中间质细胞浸润和VASH-1+细胞数量（3）肾小球VEGFR-2+细胞面积与VASH-1+细胞数（肾小球r = 0.44，p = 0.01）或髓质r = 0.63，p = 0.01）。这些结果表明，VASH-1的肾脏水平可能受到局部炎症，新月体病变和VEGFR-2的影响。
Experimental studies have demonstrated the involvement of angiogenesis-related factors in the progression of chronic kidney disease (CKD). There have so far been no reports investigating the distribution and clinical roles of Vasohibin-1 (VASH-1), a negative feedback regulator of angiogenesis, in CKD. We recruited 54 Japanese CKD patients and 6 patients who had normal renal tissues excised due to localized renal cell carcinoma. We evaluated the correlations between the renal expression level of VASH-1 and the clinical/histological parameters. VASH-1 was observed in renal endothelial/mesangial cells, crescentic lesions and interstitial inflammatory cells. Significant positive correlations were observed between 1) crescent formation and the number of VASH-1+ cells in the glomerulus (r＝0.48, p＝0.001) or cortex (r＝0.64, p＜0.0001), 2) interstitial cell infiltration and the number of VASH-1+ cells in the cortex (r＝0.34, p＝0.02), 3) the glomerular VEGFR-2+ area and the number of VASH-1+ cells in the glomerulus (r＝0.44, p＝0.01) or medulla (r＝0.63, p＝0.01). These results suggest that the renal levels of VASH-1 may be affected by local inflammation, crescentic lesions and VEGFR-2.