Validation of mobile eye-tracking as novel and efficient means for differentiating progressive supranuclear palsy from Parkinson's disease
Validation of mobile eye-tracking as novel and efficient means for differentiating progressive supranuclear palsy from Parkinson's disease
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DOI：
10.3389/fnbeh.2012.00088
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发表时间：
2012-12-13
影响因子：
3
通讯作者：
Einhaeuser, Wolfgang
中科院分区：
文献类型：
--
作者：
Marx, Svenja;Respondek, Gesine;Einhaeuser, Wolfgang
背景：进行性核上性麻痹（PSP）的主要症状是垂直扫视能力下降。客观测量设备可以帮助可靠地检测细微的眼动干扰，以提高临床诊断的灵敏度和特异性。本研究的目的是将限制性固定视频眼电图（VOG）的发现转移到可穿戴的头戴式设备，该设备可以很容易地应用于临床实践。研究方法：我们使用移动的凝视驱动摄像机装置（EyeSeeCam）对10名可能或可能的PSP患者、11名帕金森病（PD）患者和10名年龄匹配的健康对照（HC）的眼球运动进行了研究。在标准化的固定协议和在不受限制的现实生活中的情况下，当沿着沿着行走时，眼球运动进行了分析。结果：EyeSeeCam检测到PSP患者的扫视速度和幅度的明显损害，将其与PD和HC相区分。在垂直平面上的扫视差异特别明显，并且扫视比其他眼球运动更强。在标准化方案中的差异比在现实生活中的情况更明显。结论：使用EyeSeeCam对注视过程中的扫视速度和扫视幅度进行综合分析，
Background: The decreased ability to carry out vertical saccades is a key symptom of Progressive Supranuclear Palsy (PSP). Objective measurement devices can help to reliably detect subtle eye movement disturbances to improve sensitivity and specificity of the clinical diagnosis. The present study aims at transferring findings from restricted stationary video-oculography (VOG) to a wearable head-mounted device, which can be readily applied in clinical practice. Methods: We investigated the eye movements in 10 possible or probable PSP patients, 11 Parkinson's disease (PD) patients, and 10 age-matched healthy controls (HCs) using a mobile, gaze-driven video camera setup (EyeSeeCam). Ocular movements were analyzed during a standardized fixation protocol and in an unrestricted real-life scenario while walking along a corridor. Results: The EyeSeeCam detected prominent impairment of both saccade velocity and amplitude in PSP patients, differentiating them from PD and HCs. Differences were particularly evident for saccades in the vertical plane, and stronger for saccades than for other eye movements. Differences were more pronounced during the standardized protocol than in the real-life scenario. Conclusions: Combined analysis of saccade velocity and saccade amplitude during the fixation protocol with the EyeSeeCam provides a simple, rapid (