Neurobiological mechanisms of panic anxiety: biochemical and behavioral correlates of yohimbine-induced panic attacks.
Neurobiological mechanisms of panic anxiety: biochemical and behavioral correlates of yohimbine-induced panic attacks.
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惊恐焦虑的神经生物学机制：育亨宾引起的惊恐发作的生化和行为相关性。
DOI：
10.1176/ajp.144.8.1030
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Heninger,GR
中科院分区：
文献类型：
--
作者：
Charney,DS;Woods,SW;Goodman,WK;Heninger,GR
在20名健康受试者和68名伴有惊恐发作或惊恐障碍的广场恐怖症患者中，测定了α 2肾上腺素能受体拮抗剂育亨宾对焦虑、血压、心率和血浆去甲肾上腺素代谢产物3-甲氧基-4-羟基苯乙二醇（MHPG）和皮质醇水平的影响。育亨宾在37名患者和1名健康受试者中产生符合DSM-III标准的恐慌发作。与健康受试者相比，报告育亨宾引起的惊恐发作的患者血浆MHPG、皮质醇、收缩压和心率显著增加。这些研究结果支持的假说有关高去甲肾上腺素能神经元活动的病理生理学惊恐发作的一个小组的惊恐障碍患者。
The effects of yohimbine, an alpha 2-adrenergic receptor antagonist, on anxiety, blood pressure, heart rate, and plasma levels of the norepinephrine metabolite 3-methoxy-4-hydroxyphenylglycol (MHPG) and cortisol were determined in 20 healthy subjects and 68 patients who had agoraphobia with panic attacks or panic disorder. Yohimbine produced panic attacks meeting DSM-III criteria in 37 patients and one healthy subject. The patients reporting yohimbine-induced panic attacks had significantly larger increases in plasma MHPG, cortisol, systolic blood pressure, and heart rate than the healthy subjects. These findings support the hypothesis relating high noradrenergic neuronal activity to the pathophysiology of panic attacks in a subgroup of panic disorder patients.