In vivo proton magnetic resonance spectroscopy (MRS) study of post polio residual paralysis (PPRP) patients
In vivo proton magnetic resonance spectroscopy (MRS) study of post polio residual paralysis (PPRP) patients
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DOI：
10.1016/s0730-725x(02)00480-0
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发表时间：
2002-01-01
影响因子：
2.5
通讯作者：
Wadhwa, S
中科院分区：
文献类型：
--
作者：
Jagannathan, NR;Wadhwa, S
对脊髓灰质炎后残留麻痹(PPRP)患者进行的体内质子磁共振波谱研究表明，肌细胞内脂质(IMCL)的存在与否与瘫痪的严重程度有关。我们观察到，轻度瘫痪患者与对照组相比，IMCL的存在具有可比性(p>；0.05)，而中度和重度瘫痪患者在IMCL的存在方面具有可比性(p>；0.05)。此外，严重瘫痪患者肌酸、肉碱和胆碱代谢产物减少或完全消失。非侵入性地检测体内肌肉脂肪隔间的细微差异的能力可能被证明是理解肌肉疾病发病机制的有价值的工具。这可能为设计有效的康复运动计划或开发新的药物疗法提供可能性。(C)2002 Elsevier Science Inc.保留所有权利。
In-vivo proton MR spectroscopy carried out on post polio residual paralysis (PPRP) patients indicate that the presence or absence of intra-myocellular lipids (IMCL) is related to the severity of the paralysis. It is observed that mildly paralyzed patients are comparable (p > 0.05) with the control subjects in relation to the presence of IMCL, while moderate and severely paralysed patients are comparable (p > 0.05) in relation to the absence of IMCL. In addition, there is reduction or complete absence of creatine, carnitine and choline metabolites in severely paralyzed patients. The ability to detect noninvasively the subtle differences in in vivo, the lipid compartments of muscle may prove to be a valuable tool in understanding the pathogenesis of muscle diseases. This could open up the possibilities in designing effective rehabilitative exercise programs or development of new drug therapies. (C) 2002 Elsevier Science Inc. All rights reserved.