Distribution of killer cell immunoglobulin-like receptor genes in the Chinese Han population
Distribution of killer cell immunoglobulin-like receptor genes in the Chinese Han population
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DOI：
10.1111/j.1399-0039.2005.00412.x
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发表时间：
2005-06-01
期刊：
影响因子：
--
通讯作者：
Yan, LX
中科院分区：
文献类型：
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作者：
Jiang, K;Zhu, FM;Yan, LX
自然杀伤细胞上的杀伤细胞免疫球蛋白样受体（KIR）识别HLA I类等位基因组。目前已鉴定出17个KIR基因，并根据基因含量描述了两种KIR单倍型（A组和B组）。免疫遗传学分析显示，不同民族人群中A组和B组单倍型的分布存在显著差异。在这里，基因组DNA从104个健康无关的中国汉族个体进行分型的存在或不存在的KIR基因。所有17个KIR基因在群体中被观察到，并且框架基因3DL3、3DP1、2DL4和3DL2在所有个体中存在。发现了26种不同的基因型，其中4种不能根据Hsu等人的模型（J Immunol 2002：169：5118）分配到单倍型。A组单倍型与B组单倍型的频率约为3：1，其中具有两个A组单倍型的个体占58.7%。分析表明，部分KIR基因对存在明显的连锁不平衡。我们的数据表明，中国汉族人群的KIR基因频率和推定的KIR单倍型与其他一些群体相比是不同的。
Killer cell immunoglobulin-like receptors (KIRs) on natural killer cells recognize groups of HLA class I alleles. Seventeen KIR genes have been identified at present, and two kinds of KIR haplotypes (group A and B) have been described based on their gene contents. Immunogenetic analysis of different ethnic populations shows significant differences in terms of the distribution of group A and B haplotypes. Here, genomic DNA from 104 healthy unrelated Chinese Han individuals was typed for the presence or absence of KIR genes. All 17 KIR genes were observed in the population, and framework genes 3DL3, 3DP1, 2DL4, and 3DL2 were present in all individuals. Twenty-six different genotypes were found, four of which could not be assigned to haplotypes according to the model of Hsu et al. (J Immunol 2002: 169: 5118). Group A haplotypes outnumbered group B haplotypes in frequency by approximately 3 : 1, with individuals having two group A haplotypes accounting for 58.7%. Analysis indicated that some pairs of KIR genes showed remarkable linkage disequilibrium. Our data demonstrated that the Chinese Han population is distinct in KIR gene frequencies and putative KIR haplotypes in comparison to some other populations.