Brain and autonomic association accompanying stochastic decision-making
Brain and autonomic association accompanying stochastic decision-making
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DOI：
10.1016/j.neuroimage.2009.07.060
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发表时间：
2010-01-01
期刊：
影响因子：
5.7
通讯作者：
Yamada, Jitsuhiro
中科院分区：
文献类型：
--
作者：
Ohira, Hideki;Ichikawa, Naho;Yamada, Jitsuhiro
为了研究大脑和伴随决策的自主神经活动之间的功能联系，我们同时使用O-15水正电子发射断层扫描和时间锁定到奖惩反馈的事件相关脑电位(ERPs)记录了随机决策任务中的局部脑血流量以及心血管参数。我们操纵了任务中结果的不确定性；具体地说，我们比较了奖励/惩罚可预测性高的条件(偶发-奖励条件)和奖励/惩罚可预测性低的条件(随机-奖励条件)。前扣带回皮质(ACC)在这两种情况下通常都被激活。与或有奖赏条件相比，在随机奖赏条件下，被试的眼眶前额叶、右侧背外侧前额叶皮质和背侧纹状体被激活，被试必须继续寻找刺激和奖惩之间的偶然性。这些脑区的激活与反馈信号锁定的事件相关电位的积极成分(反馈相关积极程度)相关，这表明在或有奖励条件下与行为决策有关。此外，在需要持续注意和应急监测的随机奖励条件下，心血管反应被减弱，这种心血管反应的减弱是由头端ACC控制的迷走神经活动介导的。这些发现表明，前额-纹状体网络为决策提供了神经基础，并对伴随决策的外周自主神经活动进行了调节。(C)2009 Elsevier Inc.保留所有权利。
To examine the functional association between brain and autonomic activities accompanying decision-making, we simultaneously recorded regional cerebral blood flow using O-15-water positron emission tomography and event-related brain potentials (ERPs) time-locked to feedback of reward and punishment, as well as cardiovascular parameters, during a stochastic decision-making task. We manipulated the uncertainty Of Outcomes in the task; specifically, we compared a condition with high predictability of reward/punishment (contingent-reward condition) and a condition with low predictability of reward/punishment (random-reward condition). The anterior cingulate cortex (ACC) was commonly activated in both conditions. Compared with the contingent-reward condition, the orbitofrontal and right dorsolateral prefrontal cortices and dorsal striatum were activated in the random-reward condition, where subjects had to continue to seek contingency between stimuli and reward/punishment. Activation of these brain regions correlated with a positive component of ERPs locked to feedback signals (feedback-related positivity), which showed an association with behavioral decision-making in the contingent-reward condition. Furthermore, cardiovascular responses were attenuated in the random-reward condition, where continuous attention and contingency monitoring were needed, and such attenuation of cardiovascular responses was mediated by vagal activity that was governed by the rostral ACC. These findings suggest that the prefrontal-striatal network provides a neural basis for decision-making and modulation over the peripheral autonomic activity accompanying decision-making. (C) 2009 Elsevier Inc. All rights reserved.