Regulation of aromatase expression by the nuclear receptor LRH-1 in adipose tissue
Regulation of aromatase expression by the nuclear receptor LRH-1 in adipose tissue
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DOI：
10.1016/j.mce.2003.11.001
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发表时间：
2004-02-27
影响因子：
4.1
通讯作者：
Simpson, ER
中科院分区：
文献类型：
--
作者：
Clyne, CD;Kovacic, A;Simpson, ER
芳香酶是负责产生雌激素的酶，是CYP19基因的产物。该基因受许多组织特异性启动子的控制，每一种启动子都受不同的因子群调控。在正常的乳房脂肪组织中，通过脂肪特异性启动子1.4的作用，相对较低水平的芳香化酶表达。乳腺肿瘤衍生因子如前列腺素E-2(PGE(2))通过另一种启动子，即启动子II，强烈刺激芳香酸酶的表达，从而增加雌激素的驱动力和肿瘤的生长。因此，了解调控乳腺肿瘤中启动子II活性的机制可能会为乳腺癌药物的发现确定新的靶点。目前的研究描述了孤儿核受体LRH-1及其共同调节因子在调节乳房脂肪组织芳香酶表达中的作用。2003爱思唯尔爱尔兰有限公司。版权所有。
Aromatase is the enzyme responsible for estrogen production, and is the product of the CYP19 gene. This gene is under the control of many tissue-specific promoters, each of which is regulated by different cohorts of factors. In normal breast adipose tissue, relatively low levels of aromatase are expressed via the action of the adipose specific promoter 1.4. Breast tumor-derived factors such as prostaglandin E-2 (PGE(2)) strongly stimulate arolnatase expression via an alternative promoter, promoter II. leading to increased estrogenic drive and tumor growth. Understanding the mechanisms that regulate promoter II activity in tumorous breast may therefore identify new targets for breast cancer drug discovery. The current study describes the role of the orphan nuclear receptor LRH-1 and its co-regulators in modulating aromatase expression in breast adipose tissue. 2003 Elsevier Ireland Ltd. All rights reserved.