Practical and efficient Suzuki-Miyaura cross-coupling of 2-iodocycloenones with arylboronic acids catalyzed by recyclable Pd(0)/C
Practical and efficient Suzuki-Miyaura cross-coupling of 2-iodocycloenones with arylboronic acids catalyzed by recyclable Pd(0)/C
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DOI：
10.1021/jo051501b
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发表时间：
2005-10-14
影响因子：
3.6
通讯作者：
Felpin, FX
中科院分区：
文献类型：
--
作者：
Felpin, FX
第一个Suzuki-Miyaura交叉偶联2-碘代环烯酮与芳基硼酸催化10%Pd（O）/C被描述为一个有趣的替代经典的均相条件。大多数底物在温和条件下在25 ℃下在空气中在DME水溶液中反应。所描述的条件耐受宽范围的碘烯酮和硼酸。值得注意的是，该方法的特点是廉价的试剂和溶剂，毒性低，使该方法对环境无害。此外，10%的Pd（O）/C可以回收并有效地重复使用至少5次，而不会显着改变交叉偶联产物的产率。
The first Suzuki-Miyaura cross-coupling of 2-iodocycloenones with arylboronic acids catalyzed by 10% Pd(O)/C is described as an interesting alternative to classical homogeneous conditions. Most of the substrate reacted under mild condition at 25 degrees C under air in aqueous DME. The conditions described tolerate a wide range of iodoenones and boronic acids. Notably, the procedure features inexpensive reagents and solvents with low toxicity rendering the method environmentally benign. Additionally 10% Pd(O)/C could be recovered and efficiently reused at least five times without significant alteration of the yields of the cross-coupled product.