QT Prolongation and Serum Sotalol Concentration Are Highly Correlated following Intravenous and Oral Sotalol
QT Prolongation and Serum Sotalol Concentration Are Highly Correlated following Intravenous and Oral Sotalol
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静脉注射和口服索他洛尔后 QT 延长与血清索他洛尔浓度高度相关
DOI：
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
J. Molnar
中科院分区：
文献类型：
--
作者：
J. Somberg;R. Preston;V. Ranade;J. Molnar
目的：本研究的目的是评价单次低剂量口服和静脉注射索他洛尔后QT间期（QT）与血清索他洛尔浓度之间的相关性。方法：15名健康志愿者随机接受索他洛尔75 mg静脉注射2.5 h和80 mg口服。在基线和给药后7次同时获得血清索他洛尔浓度和12导联心电图。通过Bazett、Fridericia和Fraudericia公式计算心率校正QT（QTc）。索他洛尔浓度和QT测量值之间进行线性回归分析。结果：在非常低的索他洛尔剂量和血清浓度下观察到显著的QT间期延长。经口和静脉给药后，用Frachial和Fridericia公式计算的QTc间期与血清索他洛尔浓度的相关性最强，几乎相同（r = 0.97，p <0.001）。公式QTc = 0.0342（索他洛尔浓度）+398密切预测了任何索他洛尔浓度下的实际QTc。结论：在整个浓度范围内，观察到血清索他洛尔浓度与QTc延长之间存在强相关性。低剂量索他洛尔可引起显著QT间期延长。在相似浓度下，静脉注射和口服索他洛尔引起相似的QT和QTc效应。了解QT效应可用于指导进一步的剂量增加。
Objectives: The aim of this study was to evaluate the correlation between QT interval (QT) and serum sotalol concentration following a single low dose of oral and intravenous sotalol. Methods: Fifteen healthy volunteers received 75 mg intravenous sotalol over 2.5 h and 80 mg oral sotalol in a random order. Serum sotalol concentrations and 12-lead electrocardiograms were obtained simultaneously at baseline and 7 times following dosings. Rate-corrected QT (QTc) was calculated by the Bazett, Fridericia and Framingham formulas. Linear regression analysis was performed between sotalol concentrations and QT measurements. Results: Significant QT prolongation was seen at very low sotalol doses and serum concentrations. QTc intervals calculated by the Framingham and Fridericia formulas showed the strongest and virtually identical correlations with serum sotalol concentration (r ≧ 0.97, p < 0.001) following oral and intravenous administrations. The equation QTc = 0.0342 (sotalol concentration) + 398 closely predicted actual QTc at any sotalol concentration. Conclusions: A strong correlation was observed between serum sotalol concentration and QTc prolongation across the entire concentration range. Low-dose sotalol caused significant QT prolongation. At similar concentrations, intravenous and oral sotalol caused similar QT and QTc effects. Knowing the QT effect can be used to guide further dose increase.
索他洛尔的浓度依赖性药理学特性。
DOI：
10.1016/0002-9149(86)90692-2
发表时间：
1986
期刊：
The American journal of cardiology
影响因子：
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作者：
Wang,T;Bergstrand,RH;Thompson,KA;Siddoway,LA;Duff,HJ;Woosley,RL;Roden,DM
通讯作者：
Roden,DM