The role of stromal cells in inflammatory bone loss
The role of stromal cells in inflammatory bone loss
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DOI：
10.1111/cei.12979
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发表时间：
2017-07
影响因子：
4.6
通讯作者：
C. Wehmeyer;T. Pap;C. Buckley;A. Naylor
中科院分区：
文献类型：
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作者：
C. Wehmeyer;T. Pap;C. Buckley;A. Naylor
类风湿性关节炎（RA）是一种自身免疫性疾病，其特征是慢性炎症、局部和全身性骨丢失以及缺乏代偿性骨修复。成纤维细胞样滑膜细胞（FLS）是基质中最丰富的细胞，也是自身免疫性疾病（如RA）的关键群体。越来越多的证据表明，这些细胞不仅在慢性炎症和滑膜增生中发挥重要作用，而且还影响骨重建。在炎症条件下，FLS释放炎性细胞因子，调节骨破坏和形成，并与免疫细胞沟通以控制骨稳态。其他基质细胞，如成骨细胞和终末分化的成骨细胞，称为骨细胞，也参与骨稳态的调节，并在炎症期间失调。这篇综述强调了我们目前对基质细胞如何影响骨形成和骨破坏之间平衡的理解。增加我们对这些过程的理解对于开发治疗RA骨丢失的新治疗策略至关重要。
Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation, local and systemic bone loss and a lack of compensatory bone repair. Fibroblast‐like synoviocytes (FLS) are the most abundant cells of the stroma and a key population in autoimmune diseases such as RA. An increasing body of evidence suggests that these cells play not only an important role in chronic inflammation and synovial hyperplasia, but also impact bone remodelling. Under inflammatory conditions FLS release inflammatory cytokines, regulate bone destruction and formation and communicate with immune cells to control bone homeostasis. Other stromal cells, such as osteoblasts and terminally differentiated osteoblasts, termed osteocytes, are also involved in the regulation of bone homeostasis and are dysregulated during inflammation. This review highlights our current understanding of how stromal cells influence the balance between bone formation and bone destruction. Increasing our understanding of these processes is critical to enable the development of novel therapeutic strategies with which to treat bone loss in RA.