Peppermint oil (Mintoil®) in the treatment of irritable bowel syndrome:: A prospective double blind placebo-controlled randomized trial
Peppermint oil (Mintoil®) in the treatment of irritable bowel syndrome:: A prospective double blind placebo-controlled randomized trial
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DOI：
10.1016/j.dld.2007.02.006
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发表时间：
2007-06-01
影响因子：
4.5
通讯作者：
Marzio, L.
中科院分区：
文献类型：
--
作者：
Cappello, G.;Spezzaferro, M.;Marzio, L.
导论.已经研究了薄荷油在治疗肠易激综合征中的用途，其结果可变，可能是由于存在受小肠细菌过度生长、乳糖不耐受或乳糜泻影响的患者，这些患者可能具有与肠易激综合征类似的症状。本研究的目的是测试肠溶薄荷油在排除小肠细菌过度生长、乳糖不耐受和乳糜泻的肠易激综合征患者中的有效性。根据罗马II标准，57名患有肠易激综合征的患者，具有正常的乳糖和乳果糖呼气试验和乳糜泻的阴性抗体筛查，在双盲研究中用薄荷油（每天两次的两个肠溶胶囊或安慰剂）治疗4周。在治疗前（T-0）、治疗前4周（T-4）和治疗结束后4周（T-8）评估症状。评价的症状为：腹胀、腹痛或不适、腹泻、便秘、排便不完全感、排便疼痛、气体或粘液排出和排便紧迫感。对于每种症状的强度和频率，从0到4进行评分。肠易激综合征症状总评分也计算为每个症状的强度和频率评分的平均值之和的平均值。在T-4时，薄荷油组75%的患者基础（T-0）肠易激综合征总症状评分降低> 50%，而安慰剂组为38%（P < 0.009）。与T-0相比，在T-4和T-8使用薄荷油，发现肠易激综合征总症状评分在统计学上显著降低（T-0：2.19 +/- 10。13，T-4：1.07 +/- 0.10*，T-8：1.60 +/- 0.10*，T-0 < 0.01与To相比，平均值4：S.E.M.），而安慰剂组无明显变化。用薄荷油治疗4周可改善肠易激综合征患者的腹部症状。(c)2007年意大利胃肠病学编辑由爱思唯尔有限公司出版。保留所有权利。
Introduction. The use of peppermint oil in treating the irritable bowel syndrome has been studied with variable results probably due to the presence of patients affected by small intestinal bacterial overgrowth, lactose intolerance or celiac disease that may have symptoms similar to irritable bowel syndrome.Aim. The aim of the study was to test the effectiveness of enteric-coated peppermint oil in patients with irritable bowel syndrome in whom small intestinal bacterial overgrowth, lactose intolerance and celiac disease were excluded.Methods. Fifty-seven patients with irritable bowel syndrome according to the Rome II criteria, with normal lactose and lactulose breath tests and negative antibody screening for celiac disease, were treated with peppermint oil (two enteric-coated capsules twice per day or placebo) for 4 weeks in a double blind study. The symptoms were assessed before therapy T-0), after the first 4 weeks of therapy T-4) and 4 weeks after the end of therapy T-8). The symptoms evaluated were: abdominal bloating, abdominal pain or discomfort, diarrhoea, constipation, feeling of incomplete evacuation, pain at defecation, passage of gas or mucus and urgency at defecation. For each symptom intensity and frequency from 0 to 4 were scored. The total irritable bowel syndrome symptoms score was also calculated as the mean value of the sum of the average of the intensity and frequency scores of each symptom.Results. At T-4, 75% of the patients in the peppermint oil group showed a > 50% reduction of basal (T-0) total irritable bowel syndrome symptoms score compared with 38% in the placebo group (P < 0.009). With peppermint oil at T-4 and at T-8 compared with T-0 a statistically significant reduction of the total irritable bowel syndrome symptoms score was found (T-0: 2.19 +/- 10. 13, T-4: 1.07 +/- 0.10*, T-8: 1.60 +/- 0.10*, T-0 < 0.01 compared with To, mean 4: S.E.M.), while no change was found with the placebo.Conclusion. A 4 weeks treatment with peppermint oil improves abdominal symptoms in patients with irritable bowel syndrome. (c) 2007 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.