Reciprocal relationship in gene expression between FGFR1 and FGFR3:: implication for tumorigenesis
Reciprocal relationship in gene expression between FGFR1 and FGFR3:: implication for tumorigenesis
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DOI：
10.1038/sj.onc.1208254
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发表时间：
2005-01-27
期刊：
影响因子：
8
通讯作者：
Jang, JH
中科院分区：
文献类型：
--
作者：
Jang, JH
我们先前已经证明，FGFR3的表达在结直肠癌细胞中经常下调。在这里，我们已经表明，FGFR1在结直肠癌细胞中过表达，并且FGFR1和FGFR3之间的基因表达是相互排斥的。此外，我们还表明，通过引入FGFR1 siRNA破坏FGFR1表达可有效提高FGFR3表达和肿瘤抑制活性。因此，FGFR1可在结肠直肠肿瘤发生中赋予细胞克隆选择性优势，有利于增殖，而FGFR3可具有癌向恶性进展的不利负调控作用，促进分化。我们的研究结果表明，FGFR 1和FGFR 3之间的基因表达的相互关系在大肠癌的恶性进展中起着重要的作用。
We have previously demonstrated that the expression of FGFR3 is frequently downregulated in colorectal carcinoma cells. Here we have shown that FGFR1 is over-expressed in colorectal carcinoma cells and the gene expressions between FGFR1 and FGFR3 are mutually exclusive. Moreover, we have also shown that the disruption of FGFR1 expression by introducing of FGFR1 siRNA was effective in elevating FGFR3 expression and tumor suppressive activities. Thus, FGFR1 may confer a selectable advantage on clones of cells in colorectal tumorigenesis, favoring proliferation, whereas FGFR3 may have the effect of an unfavorable negative regulation of progression of the carcinomas to malignancy, promoting differentiation. Our results indicate that the reciprocal relationship in gene expression between FGFR1 and FGFR3 in colorectal tissue plays an important role in the progression of the carcinomas to malignancy.