The impact of sleep disruption on executive function in Down syndrome
The impact of sleep disruption on executive function in Down syndrome
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DOI：
10.1016/j.ridd.2013.03.009
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发表时间：
2013-06-01
影响因子：
3.1
通讯作者：
Edgin, J. O.
中科院分区：
文献类型：
--
作者：
Chen, C. -C. (JJ);Spano, G.;Edgin, J. O.
唐氏综合征患儿的睡眠障碍，特别是阻塞性睡眠呼吸暂停的发病率很高。然而，只有少数研究关注这一人群中的大龄儿童和年轻人。考虑到睡眠障碍的存在和阿尔茨海默病的早期出现，需要更多的工作来研究唐氏综合症患者的睡眠和认知之间的关系。29名患有唐氏综合征的青少年和年轻人参加了本研究。父母使用一种经过充分验证的智力残疾睡眠问题测量方法报告了他们的睡眠困难。基于将阻塞性睡眠呼吸暂停与前额叶皮质功能障碍联系起来的理论模型，我们测试了在以前的唐氏综合征研究中已被证明受损的执行功能的组成部分。首先，研究结果表明，体重指数较高的唐氏综合征患者的睡眠呼吸暂停症状的护理报告也有所增加。睡眠中断程度高的人在执行功能方面也表现出更大的困难。这些结果表明，睡眠中断可能会使年轻人的这一系列功能处于危险之中。未来的工作应该检查这种风险是否会导致痴呆症的早期发作或阿尔茨海默病的急剧下降。此外，还需要更多的研究来调查运动干预和减肥对这一人群睡眠障碍的影响。(C)2013爱思唯尔有限公司保留所有权利。
The high prevalence of sleep disorders, particularly obstructive sleep apnea, is well established in children with Down syndrome. However, only a few studies have focused on older children and young adults in this population. Given the presence of sleep disorders and the early emergence of Alzheimer's disease, more work is needed to examine the relationship between sleep and cognition in Down syndrome. Twenty-nine adolescents and young adults with Down syndrome participated in the present study. Parents reported on their sleep difficulties using a well-validated measure of sleep problems in intellectual disabilities. Based on theoretical models linking obstructive sleep apnea to prefrontal cortex dysfunction, we tested components of executive functions that have been shown to be impaired in previous studies of Down syndrome. First, results indicate that participants with Down syndrome with higher body mass index also had increased caregiver reports of sleep apnea symptoms. Individuals with high ratings of sleep disruption also showed greater difficulties with executive function. These results suggest that sleep disruption may place this set of functions at risk in young adults. Future work should examine if this risk may result in earlier onset of dementia or steeper decline with Alzheimer's disease. Further, additional studies are needed to investigate the effect of exercise interventions and weight reduction on sleep disorders in this population. (C) 2013 Elsevier Ltd. All rights reserved.