Ontogeny of hepatocyte growth factor and c-met/hgf receptor in rat pancreas
Ontogeny of hepatocyte growth factor and c-met/hgf receptor in rat pancreas
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DOI：
10.1006/bbrc.1996.1789
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发表时间：
1996-12-04
影响因子：
3.1
通讯作者：
Morisset, J
中科院分区：
文献类型：
--
作者：
Calvo, EL;Boucher, C;Morisset, J
肝细胞生长因子在上皮细胞中具有多种活性，包括有丝分裂、上皮片的解离、刺激运动和促进基质侵袭。 HGF 是由met原癌基因编码的二聚体跨膜酪氨酸激酶受体的配体。本研究的目的是通过 Northern blot 表征发育过程中大鼠胰腺中 HGF 和 c-met mRNA 的表达。我们的研究结果表明，这两种信使在大鼠胰腺的早期发育过程中同时表达。胰腺 HGF 和 c-met mRNA 水平在胎儿晚期和产后 11 天之间较高，然后在 26 天时降至非常低的水平。这个低水平一直维持到成年。我们得出结论，HGF 基因表达和 c-met 胰腺基因表达具有年龄依赖性，断奶前表达最高。这些新数据表明 HGF 及其受体可能与正常胰腺发育和成熟有关。 (C) 1996 学术出版社
Hepatocyte growth factor has several activities in epithelial cells, including mitogenesis, dissociation of epithelial sheets, stimulation of motility, and promotion of matrix invasion. HGF is the ligand of a dimeric transmembrane tyrosine kinase receptor encoded by the met proto-oncogene. The objective of this study was to characterize by Northern blot the HGF and c-met mRNA expression in rat pancreas during development. Our findings show that simultaneous expression of both messengers occurs during the early development of the rat pancreas. Pancreatic HGF and c-met mRNA levels were higher between late fetal and 11 post-natal days and then decreased to a very low lever at 26 days. This low level was maintained until the adult age. We conclude that HGF gene expression and c-met pancreatic gene expression are age dependent with the highest expression before weaning. These new data demonstrate that HGF and its receptor may be implicated in normal pancreas development and maturation. (C) 1996 Academic Press, Inc.