Association study of genetic variants of 17 diabetes-related genes/loci and cardiovascular risk and diabetic nephropathy in the Chinese She population
Association study of genetic variants of 17 diabetes-related genes/loci and cardiovascular risk and diabetic nephropathy in the Chinese She population
复制标题
中国畲族人群17个糖尿病相关基因/位点遗传变异与心血管风险和糖尿病肾病的关联研究
DOI：
10.1111/1753-0407.12025
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发表时间：
2013-06-01
影响因子：
4.5
通讯作者：
Wen, Junping
中科院分区：
文献类型：
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作者：
Chen, Gang;Xu, Yuan;Wen, Junping
背景：遗传决定在 2 型糖尿病 (T2DM) 病理学中很重要。我们研究了中国畲族受试者中 17 个糖尿病相关基因/位点、T2DM 和糖尿病并发症之间的遗传变异之间的关联。方法：利用中国畲族受试者的 17 个单核苷酸多态性进行了一项全面的基因关联研究，这些畲族受试者的糖耐量正常 (n = 1119)、血糖调节受损 (n = 1767) 和 T2DM (n = 443)。我们应用主要异常的明尼苏达法规发现来预测心血管风险，并估计肾小球滤过率来评估肾功能。结果：FTO rs8050136、WFS1 rs10010131、CDKN2A/B rs10811661、KCNJ11 rs5219、CDC123/CAMK1D rs12779790、JAZF1 中的九个变异rs864745、SLC30A8 rs13266634、CDKAL1 rs10946398 和 HHEX/IDE rs5015480 与 T2DM 显着相关（P < 0.05）。 WFS1 rs10010131 CDKN2A/B rs10811661、CDC123/CAMK1D rs12779790、JAM rs864745、FTO rs8050136 和 HHEX/IDE rs5015480 中的单核苷酸多态性与 T2DM 和血糖调节受损相关。 WFS1 rs10010131、IGF2BP2 rs4402960、CDKAL1 rs10946398、FTO rs8050136、KCATQ1 rs2237897 和 ADAMTS9 rs4607103 中的风险等位基因与稳态模型评估下降显着相关。 (HOMA)-β (P < 0.05)。调整年龄、性别和体重指数后，遗传变异 JAM rs864745、PTO rs8050136 和 HHEX/IDE rs5015480 与估计肾小球滤过率降低显着相关（P < 0.05）。 WFS1 rs10010131、CDKN2A/B rs10811661、CDC123/CAMID rs12779790、JAZF1 rs864745、FTO rs80501360、CDKAL1 rs10946398 和 HHEX/IDE rs5015480 中的遗传变异与明尼苏达州异常相关代码结果 (P < 0.05)。结论：WFS1、CDKAT2A/B、KCNJ11 中的变异。 CDC123/CAMK1D、JAZF1、SLC30A8、FTO、CDKAL1 和 HHEX/IDE 基因与中国畲族受试者中的 T2DM 显着相关。 JAZF1、FTO、CDKAL1 和 HHEX/IDE 与糖尿病肾病相关。 WFS1、CDKN2A/B、CDC123/CAMK1D、JAZF1、FTO、CDKAL1 和 HHEX/IDE 与心血管风险相关
Background: Genetic determinations are important in type 2 diabetes (T2DM) pathology. We investigated associations between genetic variants of 17 diabetes-related genes/loci, T2DM and diabetic complications in Chinese She subjects.Methods: A comprehensive gene-based association study was conducted using 17 single nucleotide polymorphisms in Chinese She subjects with normal glucose tolerance (n = 1119), impaired glucose regulation (n = 1767), and T2DM (n = 443). We applied major abnormal Minnesota Code findings to predict cardiovascular risk and estimated glomerular filtration rate to assess kidney function.Results: Nine variants in FTO rs8050136, WFS1 rs10010131, CDKN2A/B rs10811661, KCNJ11 rs5219, CDC123/CAMK1D rs12779790, JAZF1 rs864745, SLC30A8 rs13266634, CDKAL1 rs10946398, and HHEX/IDE rs5015480 were significantly associated with T2DM (P < 0.05). Single nucleotide polymorphisms in WFS1 rs10010131 CDKN2A/B rs10811661, CDC123/CAMK1D rs12779790, JAM rs864745, FTO rs8050136, and HHEX/IDE rs5015480 were associated with T2DM and impaired glucose regulation. Risk alleles in WFS1 rs10010131, IGF2BP2 rs4402960, CDKAL1 rs10946398, FTO rs8050136, KCATQ1 rs2237897, and ADAMTS9 rs4607103 were significantly associated with decreased homeostatic model assessment. (HOMA)-beta (P < 0.05). After adjusting for age, gender and body mass index, genetic variants JAM rs864745, PTO rs8050136, and HHEX/IDE rs5015480 were significantly related to reduced estimated glomerular filtration rate (P < 0.05). Genetic variants in WFS1 rs10010131, CDKN2A/B rs10811661, CDC123/CAMID rs12779790, JAZF1 rs864745, FTO rs80501360, CDKAL1 rs10946398, and HHEX/IDE rs5015480 correlated with abnormal major Minnesota Code findings (P < 0.05).Conclusion: Variants in WFS1, CDKAT2A/B, KCNJ11. CDC123/CAMK1D, JAZF1, SLC30A8, FTO, CDKAL1, and HHEX/IDE genes are significantly associated with T2DM in She Chinese subjects. JAZF1, FTO, CDKAL1, and HHEX/IDE are associated with diabetic nephropathy. WFS1, CDKN2A/B, CDC123/CAMK1D, JAZF1, FTO, CDKAL1, and HHEX/IDE are associated with cardiovascular risk