Genital herpes simplex infections: effect of asymptomatic shedding and latency on management of infections in pregnant women and neonates.
Genital herpes simplex infections: effect of asymptomatic shedding and latency on management of infections in pregnant women and neonates.
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生殖器单纯疱疹感染：无症状脱落和潜伏期对孕妇和新生儿感染管理的影响。
DOI：
10.1111/1523-1747.ep12281172
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Yeager,AS
中科院分区：
文献类型：
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作者：
Yeager,AS
在有反复生殖器感染病史的妇女中，2.4%在分娩时发生无症状的单纯疱疹病毒(HSV)脱落；使用目前的方法，这不能提前预测。此外，只有22%的受感染婴儿的母亲有反复生殖器感染的诱因。在22名无症状的暴露婴儿中，发现被动中和抗体滴度分别为1：106和1：67，而患病婴儿则分别为1：8和1：8，提示母亲的抗体转移可能是一种重要的宿主防御。在接受治疗的婴儿中，接受阿糖腺苷治疗的婴儿的抗体滴度上升速度比接受阿昔洛韦的婴儿更快；后两名婴儿在停药后出现了第二个器官的严重感染。此时，婴儿接触HSV似乎是不可避免的。结果的极端变异性可能与宿主因素有关，目前对这些因素知之甚少。
Asymptomatic shedding of herpes simplex virus (HSV) at delivery occurred in 2.4% of women with a past history of recurrent genital infections; using current methods, this could not be predicted in advance. In addition, only 22% of the mothers of infected infants had an elicitable history of recurrent genital infections. Passively derived neutralizing antibody titers of 1:106 to HSV-1 and 1:67 to HSV-2 were found in 22 exposed infants who remained asymptomatic as compared with 1:8 and 1:8, respectively, in ill infants, suggesting that transfer of antibody from the mother may be an important host defense. Among treated infants, a more rapid rise in antibody titer was seen in infants receiving adenine arabinoside than in those receiving acyclovir; two of the latter infants developed a severe infection in a second organ following cessation of the drug. Exposure of infants to HSV appears inevitable at this time. The extreme variability in outcome is probably related to host factors that are poorly understood at present.