DELTA-9-TETRAHYDROCANNABINOL AS AN ANTI-EMETIC IN CANCER-PATIENTS RECEIVING HIGH-DOSE METHOTREXATE - PROSPECTIVE, RANDOMIZED EVALUATION
DELTA-9-TETRAHYDROCANNABINOL AS AN ANTI-EMETIC IN CANCER-PATIENTS RECEIVING HIGH-DOSE METHOTREXATE - PROSPECTIVE, RANDOMIZED EVALUATION
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DOI：
10.7326/0003-4819-91-6-819
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发表时间：
1979-01-01
影响因子：
39.2
通讯作者：
ROSENBERG, SA
中科院分区：
文献类型：
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作者：
CHANG, AE;SHILING, DJ;ROSENBERG, SA
对15名接受大剂量甲氨蝶呤化疗的骨肉瘤患者进行了一项随机、双盲、安慰剂对照试验，研究对象是口服和烟熏β-9-四氢大麻酚(THC)作为止吐剂。每个患者作为他或她自己的对照。在15名患者中，与安慰剂相比，14名患者THC的恶心和呕吐有所减少。β-9-THC在减少呕吐和呕吐发作次数、恶心程度、恶心持续时间和呕吐量方面明显比安慰剂有效(P<；0.001)。服用安慰剂的患者恶心和呕吐的发生率为72%。当血浆THC浓度为5.0 ng/ml、5.0~10.0 ng/ml、10.0 ng/ml时，恶心、呕吐发生率分别为44%、21%、6%。在接受大剂量甲氨蝶呤治疗的患者中，与安慰剂相比，THC似乎具有显著的止吐特性。
Fifteen patients with osteogenic sarcoma receiving high-dose methotrexate chemotherapy were studied in a randomized, double-blind, placebo-controlled trial of oral and smoked .delta.-9-tetrahydrocannabinol (THC) as an antiemetic. Each patient served as his or her own control. Of 15 patients, 14 had a reduction in nausea and vomiting on THC as compared to placebo. .delta.-9-THC was significantly more effective than placebo in reducing the number of vomiting and retching episodes, degree of nausea, duration of nausea, and volume of emesis (P < 0.001). There was a 72% incidence of nausea and vomiting on placebo. When plasma THC concentrations measured < 5.0 ng/ml, 5.0 to 10.0 ng/ml, and > 10.0 ng/ml, the incidences of nausea and vomiting were 44%, 21%, and 6%, respectively. THC appears to have significant antiemetic properties when compared with placebo in patients receiving high-dose methotrexate.