Links between innate immunity and normal tissue radiobiology.
Links between innate immunity and normal tissue radiobiology.
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DOI：
10.1667/rr1931.1
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发表时间：
2010-04
影响因子：
3.4
通讯作者：
McBride WH
中科院分区：
文献类型：
--
作者：
Schaue D;McBride WH
身体通过与微生物“非我”相同的受体超家族成员感知来自“受损自我”分子的“危险”，触发导致急性炎症反应产生的经典信号通路。由于这个原因，正常组织对中等和临床相关剂量辐射的反应的生物学与先天免疫密不可分。炎症事件的复杂序列引起进一步的细胞和组织损伤以消除潜在的入侵者，但也导致限制损伤扩散的细胞保护反应和通过组织再生或替换的伤口愈合。这些连续的过程是通过多种反馈控制机制协调的，这些机制涉及辐射和免疫信号传导共同的自由基和细胞因子的周期性产生。这需要常驻组织和炎性细胞类型的协同努力，巨噬细胞显然是领导者。因此，对中等剂量辐射的初始反应进入促炎范例，其最终结果严重依赖于参与组织损伤、再生和修复的免疫细胞的特性，并且部分地受到遗传影响。重要的是，这些典型的途径提供了旨在改变正常组织辐射反应的干预措施的目标。在这篇综述中，我们研究了先天免疫和正常组织放射生物学之间的交叉领域。
The body senses “danger” from “damaged self” molecules through members of the same receptor superfamily it uses for microbial “non-self”, triggering canonical signaling pathways that lead to the generation of acute inflammatory responses. For this reason, the biology of normal tissue responses to moderate and clinically relevant doses of radiation is inextricably connected to innate immunity. The complex sequence of inflammatory events that ensues causes further cell and tissue damage to eliminate potential invaders but also leads to cytoprotective responses that limit the spread of damage and to wound healing through tissue regeneration or replacement. These sequential processes are orchestrated through multiple feedback control mechanisms involving cyclical production of free radicals and cytokines that are common to both radiation and immune signaling. This requires a concerted effort by resident tissue and inflammatory cell types, with macrophages apparently leading the way. The initial response to moderate doses of radiation therefore feeds into a pro-inflammatory paradigm whose eventual outcome is critically dependent upon the properties of the immune cells that are involved in tissue damage, regeneration and repair and that are in part under genetic influence. Importantly, these canonical pathways provide targets for interventions aimed at modifying normal tissue radiation responses. In this review, we examine areas of intersection between innate immunity and normal tissue radiobiology.