Breast Carcinoma Updates in Molecular Profiling 2018
Breast Carcinoma Updates in Molecular Profiling 2018
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DOI：
10.1016/j.cll.2018.02.006
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发表时间：
2018-06-01
影响因子：
1.7
通讯作者：
Ali-Fehmi, Rouba
中科院分区：
文献类型：
--
作者：
Bandyopadhyay, Sudeshna;Bluth, Martin H.;Ali-Fehmi, Rouba
乳腺癌分子亚型的最重要的贡献是雌激素阳性和雌激素阴性肿瘤亚型的鉴定。了解这些肿瘤中的遗传改变将有助于临床医生确定新的治疗靶点。了解原位癌向浸润癌转变的进展途径可能会导致这些患者有效的风险分层。癌症基因组分析网络收集了基因组和表观基因组数据，以提供有关致癌作用和途径相互作用的全面信息。这些信息提高了对疾病过程的理解，也为识别治疗的靶向突变提供了更准确的信息。
The most significant contribution of molecular subtyping of breast carcinomas has been the identification of estrogen-positive and estrogen-negative tumor subtypes. Knowledge of genetic alterations in these tumors will help clinicians identify novel therapeutic targets. Understanding the progression pathways involved in the transition of in situ carcinoma to invasive carcinoma might lead to efficient risk stratification in these patients. The Cancer Genome Analysis Network has collected genomic and epigenomic data to provide comprehensive information regarding carcinogenesis and pathway interactions. Such information improves the understanding of the disease process and also provides more accurate information toward identifying targetable mutations for treatment.