The pulmonary mesenchyme directs lung development.
The pulmonary mesenchyme directs lung development.
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DOI：
10.1016/j.gde.2015.01.011
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发表时间：
2015-06
影响因子：
4
通讯作者：
Sun X
中科院分区：
文献类型：
--
作者：
McCulley D;Wienhold M;Sun X
呼吸系统发育的每个步骤都依赖于肺上皮和间质复杂的相互作用和协调发育。过去，人们对上皮细胞的关注多于对间充质的关注。间充质是规范和形态发生信号的来源，也是许多对正常肺发育和功能至关重要的极其复杂的细胞谱系的来源。这篇综述重点介绍了最近集中于间充质的研究，该研究揭示了间充质在呼吸谱系规范、分支形态发生、上皮分化、谱系区分、血管发育和肺泡成熟过程中在其他细胞层背景下发育的遗传和表观遗传机制。
Each of the steps of respiratory system development relies on intricate interactions and coordinated development of the lung epithelium and mesenchyme. In the past, more attention has been paid to the epithelium than the mesenchyme. The mesenchyme is a source of specification and morphogenetic signals as well as a host of surprisingly complex cell lineages that are critical for normal lung development and function. This review highlights recent research focusing on the mesenchyme that has revealed genetic and epigenetic mechanisms of its development in the context of other cell layers during respiratory lineage specification, branching morphogenesis, epithelial differentiation, lineage distinction, vascular development, and alveolar maturation.
影响因子：
3.7
作者：
Miller MF;Cohen ED;Baggs JE;Hogenesch JB;Morrisey EE
通讯作者：
Morrisey EE