Genetics of atopy and asthma: The rationale behind promoter-based candidate gene studies (IL-4 and IL-10)
Genetics of atopy and asthma: The rationale behind promoter-based candidate gene studies (IL-4 and IL-10)
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DOI：
10.1164/ajrccm.156.4.12tac-14
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发表时间：
1997-10-01
影响因子：
24.7
通讯作者：
Borish, L
中科院分区：
文献类型：
--
作者：
Rosenwasser, LJ;Borish, L
特应性和哮喘的遗传学已成为一个非常有趣的研究领域。通过哮喘或支气管高反应性的免疫发病机制确定的潜在候选基因，或通过全基因组筛选发现的潜在候选基因，将导致诊断哮喘的新的和更好的方法，更重要的是，与在各种基因组筛选工作中确定的候选基因的产物相关的药物发现的潜力。候选基因的方法已被应用到启动子区的一些细胞因子基因，内和外的人5 q33细胞因子基因簇。作为这两种细胞因子的原型，与白细胞介素（IL）-4启动子多态性和IL-10启动子多态性相关的工作将被审查，为这些细胞因子基因在哮喘中的失调提供潜在的分子机制。
The genetics of atopy and asthma has become a very interesting area for research. Potential candidate genes identified either by the immunopathogenesis of asthma or bronchial hyperresponsiveness, or uncovered by the whole-genome screen, will lead to new and better ways of diagnosing asthma and, more importantly, the potential for drug discovery related to the products of the candidate genes identified in the various genome screening efforts. The candidate gene approach has been applied to the promoter region of a number of cytokine genes, both within and outside of the human 5q33 cytokine gene cluster. As a prototype for both cytokines, work relating to an interleukin (IL)-4 promoter polymorphism and an IL-10 promoter polymorphism will be reviewed as providing a potential molecular mechanism for dysregulation of these cytokine genes in asthma.