Inflammation does not decrease intraluminal pH in chronic inflammatory bowel disease
Inflammation does not decrease intraluminal pH in chronic inflammatory bowel disease
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DOI：
10.1023/a:1026664105112
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发表时间：
1999-07-01
影响因子：
3.1
通讯作者：
Press, AG
中科院分区：
文献类型：
--
作者：
Ewe, K;Schwartz, S;Press, AG
肠道炎症可能会影响肠腔内的pH值。对15例回盲区活动性克罗恩病患者的胃肠道pH值进行了测定。此外，还对5名中度(1)或重度(4)溃疡性结肠炎患者进行了研究。15名健康受试者作为对照。用自由漂浮式pH敏感遥测胶囊测量胃肠道不同部位的管腔内pH。一个金属球连接到胶囊上，通过金属探测器进行精确定位，整个胃肠道包括发炎的部分都保持着PH值的生理模式。克罗恩病患者回肠末端pH值中位数为7.5比7.7，溃疡性结肠炎患者直肠pH值中位数为7.8比7.2。总之，腔内pH不会因克罗恩病和溃疡性结肠炎的炎性变化而降低，这使得优格列格包衣的pH控释制剂美沙拉秦也可以在病变区域溶解。
Intestinal inflammation may influence intraluminal pH. Profiles of the gastrointestinal pH were evaluated in 15 patients with active Crohn's disease of the ileocecal area. In addition, five patients with moderate (1) or severe (4) ulcerative colitis were studied. Fifteen healthy subjects served as controls. Intraluminal pH of the different parts of the gastrointestinal tract was measured by a free-floating pH-sensitive telemetering capsule. A metal sphere was attached to the capsule for exact localization by a metal detector, Physiological patterns of pH were maintained throughout the gastrointestinal tract including the inflamed segments. Median pH in the terminal ileum of the patients with Crohn's disease was 7.5 vs 7.7 and in the rectum in ulcerative colitis 7.8 vs 7.2 in the controls. In conclusion, intraluminal pH is not decreased by inflammatory changes in Crohn's disease and ulcerative colitis, allowing eudragit-coated pH-controlled-release formulations of mesalazine to dissolve in diseased areas also.