Right, but not left, posterior superior temporal gyrus is causally involved in vocal feedback control
Right, but not left, posterior superior temporal gyrus is causally involved in vocal feedback control
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DOI：
10.1016/j.neuroimage.2023.120282
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发表时间：
2023-07-20
期刊：
影响因子：
5.7
通讯作者：
Liu，Hanjun
中科院分区：
文献类型：
--
作者：
Liu，Dongxu;Chang，Yichen;Liu，Hanjun
颞后上回（pSTG）参与了听觉反馈和运动系统的整合，从而控制声音的产生。然而，关于pSTG是否以及如何参与声音反馈控制的问题目前尚不清楚。为此，本研究采用连续θ波爆发刺激（c-TBS）选择性刺激健康受试者的左或右pSTG，然后利用事件相关电位研究音调调节过程中听觉反馈改变的神经行为变化。结果表明，与对照（顶点）刺激相比，c-TBS在右侧pSTG上导致音调扰动的声音补偿较小，同时伴有较小的皮层N1和较大的P2反应。P2反应的增强受到右侧颞叶和顶叶区域以及脑岛的影响，并与声音代偿抑制显著相关。令人惊讶的是，当将c-TBS与左侧pSTG与对照刺激进行比较时，没有发现这些影响。我们的研究结果首次提供了证据，支持右脑（而非左脑）pSTG与声音音高调节的听觉-运动整合之间存在因果关系。这支持了pSTG的右偏侧贡献，不仅在自下而上的声音反馈错误检测中，而且在自上而下的方式中参与了驱动电机命令的错误纠正。
The posterior superior temporal gyrus (pSTG) has been implicated in the integration of auditory feedback and motor system for controlling vocal production. However, the question as to whether and how the pSTG is causally involved in vocal feedback control is currently unclear. To this end, the present study selectively stimulated the left or right pSTG with continuous theta burst stimulation (c-TBS) in healthy participants, then used event-related potentials to investigate neurobehavioral changes in response to altered auditory feedback during vocal pitch regulation. The results showed that, compared to control (vertex) stimulation, c-TBS over the right pSTG led to smaller vocal compensations for pitch perturbations accompanied by smaller cortical N1 and larger P2 responses. Enhanced P2 responses received contributions from the right-lateralized temporal and parietal regions as well as the insula, and were significantly correlated with suppressed vocal compensations. Surprisingly, these effects were not found when comparing c-TBS over the left pSTG with control stimulation. Our findings provide evidence, for the first time, that supports a causal relationship between right, but not left, pSTG and auditory-motor integration for vocal pitch regulation. This lends support to a right-lateralized contribution of the pSTG in not only the bottom-up detection of vocal feedback errors but also the involvement of driving motor commands for error correction in a top-down manner.