Are the arginine vasopressin V1a receptor microsatellites related to hypersexuality in children with a prepubertal and early adolescent bipolar disorder phenotype?
Are the arginine vasopressin V1a receptor microsatellites related to hypersexuality in children with a prepubertal and early adolescent bipolar disorder phenotype?
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精氨酸加压素 V1a 受体微卫星是否与青春期前和青春期早期双相情感障碍表型儿童的性欲亢进有关？
DOI：
10.1111/j.1399-5618.2005.00259.x
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发表时间：
2005
影响因子：
5.4
通讯作者：
CookJr,EdwinH
中科院分区：
文献类型：
--
作者：
Geller,Barbara;Tillman,Rebecca;Badner,JudithA;CookJr,EdwinH
目的：研究在青春期前和青春期早期双相情感障碍表型（PEA‐BP）的先显子中，5 '侧侧翼精氨酸加压素V1a受体（AVPR1A）微卫星(包括[(GATA)14]和复杂的[(CT)4‐TT‐（CT）8‐（GT）24]重复序列的家族遗传。根据文献中的临床前研究报告，假设AVPR1A微卫星重复序列的数量优先传播给性欲亢进和不受约束的人。方法：先证者为83名正在进行的PEA‐BP对照研究的参与者。PEA - BP表型由DSM - IV躁狂症定义，至少有一种躁狂症的主要症状（兴高采烈和/或浮夸），以避免仅通过与注意缺陷多动障碍（ADHD）重叠的症状来诊断躁狂症。先证者的综合评估包括单独的华盛顿大学圣路易斯儿童情感障碍和精神分裂症时间表（WASH - U - KSADS）对父母关于孩子和孩子关于自己的访谈。根据相应的WASH - U - KSADS项目评估性欲亢进和不受抑制的寻人行为。利用荧光标记引物对AVPR1A重复序列进行微卫星基因分型，并用激光诱导荧光检测。在半自动等位基因调用软件的帮助下确定等位基因。GATA重复序列有32个完整的生物学三联序列（28个信息家族），复杂重复序列有34个完整的生物学三联序列（30个信息家族）。采用病例对照和基于家庭的关联方法对数据进行分析。结果：通过传播不平衡测试，AVPR1A GATA或复杂重复序列的优先传播在性欲过度或不受抑制的人群中并不显著。同样，病例对照分析发现，性欲亢进或不受抑制的寻人行为与AVPR1A GATA或复合体重复序列的数量之间没有显著关联。当p < 0.05时，检测等位基因频率分别为0.1和0.5的比值比为5.0和4.0（在基于家庭的分析中）和3.5和2.6（在病例对照分析中）的比值比约为80%。结论：不支持AVPR1A优先传播给性欲亢进或不受抑制的人寻找先证者。
Objective:To examine family‐based transmission of the number of 5′ flanking arginine vasopressin V1a receptor (AVPR1A) microsatellites, which include [(GATA)14] and complex [(CT)4‐TT‐(CT)8‐(GT)24] repeats, in probands with a prepubertal and early adolescent bipolar disorder phenotype (PEA‐BP). Preferential transmission of the number of AVPR1A microsatellite repeats to hypersexual and uninhibited people‐seeking probands was hypothesized, based on reports from preclinical work in the literature.Methods:Probands were 83 participants in an ongoing controlled study of PEA‐BP. The PEA‐BP phenotype was defined by DSM‐IV mania with at least one of the cardinal symptoms of mania (elation and/or grandiosity) to avoid diagnosing mania only by symptoms that overlapped with those for attention‐deficit hyperactivity disorder (ADHD). Comprehensive assessment of the probands included separate Washington University in St. Louis Kiddie Schedule for Affective Disorders and Schizophrenia (WASH‐U‐KSADS) interviews of parents about their children and of children about themselves. Hypersexuality and uninhibited people‐seeking were assessed from the corresponding WASH‐U‐KSADS items. Microsatellite genotyping of the AVPR1A repeats was conducted using fluorescently labeled primers and detected by laser‐induced fluorescence. Alleles were determined with the assistance of semi‐automated allele‐calling software. There were 32 complete, biological trios (28 informative families) for the GATA repeat and 34 complete, biological trios (30 informative families) for the complex repeat. Data were analyzed using case–control and family‐based association methods.Results:Preferential transmission of AVPR1A GATA or complex repeats was not significant for hypersexuality or uninhibited people‐seeking, using the transmission disequilibrium test. Similarly, case–control analyses found no significant associations between hypersexuality or uninhibited people‐seeking and the number of AVPR1A GATA or complex repeats. For p < 0.05, there was about 80% power to detect odds ratios of 5.0 and 4.0 (in the family‐based analyses) and 3.5 and 2.6 (in the case–control analyses), for allele frequencies of 0.1 and 0.5, respectively.Conclusion:Preferential transmission of AVPR1A to hypersexual or uninhibited people‐seeking probands was not supported.