3D printing of bone substitute implants using calcium phosphate and bioactive glasses
3D printing of bone substitute implants using calcium phosphate and bioactive glasses
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DOI：
10.1016/j.jeurceramsoc.2010.04.037
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发表时间：
2010-09-01
影响因子：
5.7
通讯作者：
Fischer, Horst
中科院分区：
文献类型：
--
作者：
Bergmann, Christian;Lindner, Markus;Fischer, Horst
定制的骨置换植入物对外科医生以美学的方式重塑颌面或颅面缺损有很大的帮助，并显着减少手术时间。这项研究的假设是，β-磷酸三钙（β-TCP）和类似于45 S5 Henchglass（R）的生物活性玻璃的复合材料适合通过3D打印工艺制造定制的植入物。选择该复合材料是因为β-TCP的生物吸收特性、其作为骨水泥反应的能力以及生物活性玻璃从惰性到生物可吸收的可调节性。定制的植入物是使用3D打印技术制造的。烧结后，打印样品的四点弯曲强度为14.9 MPa。XRD分析揭示了另外两个相的存在，CaNaPO（4）和CaSiO（3），两者都具有生物相容性和生物降解的潜力。我们的结论是，它是可能的打印定制的骨替代植入物使用生物活性TCP/玻璃复合材料。玻璃在印刷过程中不作为反应物质参与。这提供了改变玻璃组成的机会，从而改变植入物的组成。(C)2010爱思唯尔有限公司版权所有。
Customized implants for bone replacement are a great help for a surgeon to remodel maxillofacial or craniofacial defects in an esthetical way, and to significantly reduce operation times. The hypothesis of this study was that a composite of beta-tricalcium phosphate (beta-TCP) and a bioactive glass similar to the 45S5 Henchglass (R) is suitable to manufacture customized implants via 3D-printing process. The composite was chosen because of the bioresorption properties of the beta-TCP, its capability to react as bone cement, and because of the adjustability of the bioactive glass from inert to bioresorbable. Customized implants were manufactured using the 3D-printing technique. The four point bending strength of the printed specimens was 14.9 MPa after sintering. XRD analysis revealed the occurrence of two other phases, CaNaPO(4) and CaSiO(3), both biocompatible and with the potential of biodegradation. We conclude that it is possible to print tailored bone substitute implants using a bioactive TCP/glass composite. The glass is not involved as reactive substance in the printing process. This offers the opportunity to alter the glass composition and therefore to vary the composition of the implant. (C) 2010 Elsevier Ltd. All rights reserved.