Further studies on hepatic stimulatory substance (SS) after partial hepatectomy.
Further studies on hepatic stimulatory substance (SS) after partial hepatectomy.
复制标题
肝部分切除术后肝刺激物质（SS）的进一步研究。
DOI：
10.1016/0022-4804(80)90014-1
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发表时间：
1980
期刊：
影响因子：
--
通讯作者：
Terblanche,J
中科院分区：
文献类型：
--
作者：
Starzl,TE;Porter,KA;Hayashida,N;Schechter,P;Terblanche,J
刺激物质（SS），发现在细胞质中的再生狗肝，并促进再生时，注入门静脉后Eck瘘没有引起肾小球增生时，活性细胞质注入肾动脉。这一发现与肝SS的器官特异性一致，但不能证明肝SS的器官特异性。在部分肝切除的同时切除所有非肝内脏器官，可完全防止SS的发生。这一发现表明，SS在胞质溶胶捐助者是一个功能，而不是再生的启动器，一个依赖于合作的肝外（包括内脏肝营养）因素。
The stimulatory substance (SS) that is found in the cytosol of regenerating dog livers and which promoted regeneration when injected into the portal vein after Eck fistula did not cause glomerular proliferation when active cytosol was injected into the renal artery. The finding was compatible with but did not prove organ specificity of hepatic SS. The development of SS was completely prevented by extirpation of all nonhepatic splanchnic organs at the same time as partial hepatectomy. This finding indicated that SS in the cytosol donors was a feature rather than an initiator of regeneration, and one that depended upon the collaboration of extrahepatic (including splanchnic hepatotrophic) factors.