Interactions of lipoic acid radical cations with vitamins C and E analogue and hydroxycinnamic acid derivatives.
Interactions of lipoic acid radical cations with vitamins C and E analogue and hydroxycinnamic acid derivatives.
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DOI：
10.1016/s0003-9861(02)00411-3
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发表时间：
2002-10
影响因子：
3.9
通讯作者：
Changyuan Lu;Yanyun Liu
中科院分区：
文献类型：
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作者：
Changyuan Lu;Yanyun Liu
作为一种强大的天然抗氧化剂，硫辛酸在体内和体外通过使活性氧和氮物种失活而发挥出显著的抗氧化活性。在这项研究中，我们提出了一种新的硫辛酸与其他内源或外源抗氧化剂的协同作用。抗氧化剂维生素C和维生素E类似物(Trolox C)和羟基肉桂酸衍生物通过向硫辛酸自由基阳离子提供电子来循环利用硫辛酸，从而提高硫辛酸在体内和体外的抗氧化能力。电子转移速率常数为109dm3mol−1s−1数量级，接近扩散控制极限，转移量子产率大于95%。
As a powerful natural antioxidant, lipoic acid exerts significant antioxidant activities in vivo and in vitro by deactivation of reactive oxygen and nitrogen species. In this study we present a novel synergistic interaction of lipoic acid with other endogenous or exogenous antioxidants. Antioxidants vitamins C and E analogue (Trolox C) and hydroxycinnamic acid derivatives were found to recycle lipoic acid by donating electrons to lipoic acid radical cations, thereby increasing the antioxidant capacity of lipoic acid in vivo and in vitro. The rate constant of the electron transfer is in the order 109dm3mol−1s−1, close to the diffusion-controlled limit, and transfer quantum yield is above 95%.