The neurobiology of social play and its rewarding value in rats.
The neurobiology of social play and its rewarding value in rats.
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社交游戏的神经生物学及其对大鼠的奖励价值。
DOI：
10.1016/j.neubiorev.2016.07.025
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发表时间：
2016
影响因子：
8.2
通讯作者：
Trezza,Viviana
中科院分区：
文献类型：
--
作者：
Vanderschuren,LoukJMJ;Achterberg,EJMarijke;Trezza,Viviana
在包括人类在内的许多哺乳动物物种的年轻人中，一种充满活力和高度奖励的社会活动被大量表达，称为社会游戏行为。社会游戏被认为是重要的社会，认知和情感过程及其神经基础的发展，它是在儿科精神疾病中断。在这里，我们总结了最近的进展，我们的理解的大脑机制的社会游戏行为，重点是其奖励属性。阿片类物质、内源性大麻素、多巴胺和去甲肾上腺素系统在社会游戏的调节中起着重要作用。其中，多巴胺对社交游戏的动机特性尤为重要。丘脑核已被确定为阿片和多巴胺调节社交游戏的关键部位。内源性大麻素对社交游戏的影响依赖于基底外侧杏仁核，而去甲肾上腺素则通过基底外侧杏仁核、缰核和前额叶皮质调节社交游戏。总之，社交游戏行为是皮质边缘结构网络及其单胺、阿片类和内源性大麻素神经支配协调活动的结果。
In the young of many mammalian species, including humans, a vigorous and highly rewarding social activity is abundantly expressed, known as social play behaviour. Social play is thought to be important for the development of social, cognitive and emotional processes and their neural underpinnings, and it is disrupted in pediatric psychiatric disorders. Here, we summarize recent progress in our understanding of the brain mechanisms of social play behaviour, with a focus on its rewarding properties. Opioid, endocannabinoid, dopamine and noradrenaline systems play a prominent role in the modulation of social play. Of these, dopamine is particularly important for the motivational properties of social play. The nucleus accumbens has been identified as a key site for opioid and dopamine modulation of social play. Endocannabinoid influences on social play rely on the basolateral amygdala, whereas noradrenaline modulates social play through the basolateral amygdala, habenula and prefrontal cortex. In sum, social play behaviour is the result of coordinated activity in a network of corticolimbic structures, and its monoamine, opioid and endocannabinoid innervation.