Association between cigarette smoking and colorectal cancer in the women's health initiative
Association between cigarette smoking and colorectal cancer in the women's health initiative
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DOI：
10.1093/jnci/djm176
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发表时间：
2007-11-21
影响因子：
10.3
通讯作者：
Hunt, Julie R.
中科院分区：
文献类型：
--
作者：
Paskett, Electra D.;Reeves, Katherine W.;Hunt, Julie R.
将吸烟与结直肠癌风险联系起来的证据并不一致。我们调查了146877名妇女健康倡议参与者中主动吸烟和被动吸烟与结直肠癌之间的关系。女性在登记时报告了详细的吸烟史。估计吸烟与结直肠癌总体和部位特异性风险之间关系的风险比（HR）和95%置信区间（CI）。在平均7.8年（范围=0.003-11.2年）的随访中，1242名妇女被诊断为浸润性结直肠癌。在校正分析中，大多数吸烟措施与浸润性结直肠癌风险之间存在统计学显著正相关。研究中心特异性分析表明，与从不吸烟者相比，目前吸烟者患直肠癌的风险在统计学上显著增加（HR=1.95，95% CI=1.10至3.47），但结肠癌的风险没有显著增加（HR=1.03，95% CI=0.77至1.38）。在校正分析中，被动吸烟暴露与结直肠癌无关。因此，主动暴露于吸烟似乎是直肠癌的一个危险因素。
The evidence linking cigarette smoking to the risk of colorectal cancer is inconsistent. We investigated the associations between active and passive smoking and colorectal cancer among 146 877 Women's Health Initiative participants. Women reported detailed smoking histories at enrollment. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated for the association between smoking and overall and site-specific risk of colorectal cancer. Invasive colorectal cancer was diagnosed in 1242 women over an average of 7.8 years (range=0.003-11.2 years) of follow-up. In adjusted analyses, statistically significant positive associations were observed between most measures of cigarette smoking and risk of invasive colorectal cancer. Site-specific analyses indicated that current smokers had a statistically significantly increased risk of rectal cancer (HR=1.95, 95% CI=1.10 to 3.47) but not colon cancer (HR=1.03, 95% CI=0.77 to 1.38), compared with never smokers. Passive smoke exposure was not associated with colorectal cancer in adjusted analyses. Thus, active exposure to cigarette smoking appears to be a risk factor for rectal cancer.