Poliovirus detection in wastewater and stools following an immunization campaign in Havana, Cuba
Poliovirus detection in wastewater and stools following an immunization campaign in Havana, Cuba
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DOI：
10.1093/ije/dyg185
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发表时间：
2003-10-01
影响因子：
7.7
通讯作者：
Cruz, RG
中科院分区：
文献类型：
--
作者：
Lago, PM;Gary, HE;Cruz, RG
背景最近由疫苗衍生病毒引起的脊髓灰质炎暴发引起了人们对疫苗衍生脊髓灰质炎病毒在根除后可能继续传播的担忧。在这些暴发中，病毒在被发现之前似乎已经复制了2年以上。早期发现对于有效应对这些疫情至关重要。虽然急性弛缓性麻痹（AFP）监测仍将是脊髓灰质炎病毒检测的标准，但废水采样可能是一种有益的补充。在这项研究中，我们通过同时收集10岁以下儿童的粪便来评估废水采样的敏感性。
Background Recent outbreaks of poliomyelitis caused by vaccine-derived virus have raised concerns that vaccine-derived poliovirus may continue to circulate after eradication. In these outbreaks, the virus appears to have replicated for greater than or equal to2 years before detection. Early detection is critical for an effective response to these outbreaks. Although acute flaccid paralysis (AFP) surveillance will remain the standard for poliovirus detection, wastewater sampling could be a useful supplement. In this study, we evaluated the sensitivity of wastewater sampling by concurrently collecting stools from children aged