Role of adherence of Streptococcus pneumoniae in acute otitis media.
Role of adherence of Streptococcus pneumoniae in acute otitis media.
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肺炎链球菌粘附在急性中耳炎中的作用。
DOI：
10.1097/00006454-198807000-00005
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Edén,CS
中科院分区：
文献类型：
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作者：
Andersson,B;Gray,BM;DillonJr,HC;Bahrmand,A;Edén,CS
研究肺炎链球菌对人鼻咽上皮细胞的粘附，作为急性中耳炎（AOM）发生的可能决定因素。在一项关于肺炎球菌携带和感染的前瞻性研究中，从出生后婴儿的鼻咽（NP）和中耳液中获得肺炎球菌分离株。从19名AOM婴儿中分离出33株中耳液，并将其与从每个儿童急性感染时和其他情况下采集的NP培养物中回收的143株菌株进行了比较。我们研究了来自29名没有肺炎球菌感染的“携带者”婴儿的171株NP菌株，以进行比较。粘附特性与任何特定的肺炎球菌荚膜类型无关，在AOM婴儿中粘附菌株也不常见。没有证据支持与AOM相关的肺炎球菌具有特殊的粘附倾向的假设。粘附是从NP中回收的肺炎球菌的常见特征，特别是与上呼吸道感染有关，并且可能是建立定植所需的，但不是区分携带菌株和引起AOM的菌株的属性。
The adherence of Streptococcus pneumoniae to human nasopharyngeal epithelial cells was studied as a possible determinant in the development of acute otitis media (AOM). Pneumococcal isolates were obtained from the nasopharynx (NP) and middle ear fluid of infants followed from birth in a prospective study of pneumococcal carriage and infection. The adherence of 33 middle ear fluid isolates from 19 infants with AOM was compared with 143 strains recovered from NP cultures taken from each child both at the time of their acute infections and on other occasions. We studied 171 NP isolates from 29 “carrier” infants, who had no pneumococcal infections, for comparison. Adherence properties were not associated with any particular pneumococcal capsular types, nor were adherent strains more frequent among infants with AOM. There was no evidence to support the hypothesis that pneumococci associated with AOM have a special propensity for adherence. Adherence was a frequent characteristic of pneumococci recovered from the NP, especially in connection with upper respiratory tract infection, and may be required for the establishment of colonization but was not a property that discriminated between carriage strains and those causing AOM.