Prevalence of peripheral and extra-articular disease in ankylosing spondylitis versus non-radiographic axial spondyloarthritis: a meta-analysis
Prevalence of peripheral and extra-articular disease in ankylosing spondylitis versus non-radiographic axial spondyloarthritis: a meta-analysis
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强直性脊柱炎与非放射学轴性脊柱关节炎中外周及关节外疾病的患病率：一项荟萃分析
DOI：
10.1186/s13075-016-1093-z
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发表时间：
2016-09-01
影响因子：
4.9
通讯作者：
Baeten, Dominique L.
中科院分区：
文献类型：
--
作者：
de Winter, Janneke J.;van Mens, Leonieke J.;Baeten, Dominique L.
背景资料：外周疾病（关节炎、附着点炎和指关节炎）和关节外疾病（葡萄膜炎、银屑病和炎症性肠病）在强直性脊柱炎（AS）和非放射学中轴性脊柱关节炎（nr-axSpA）中很常见。然而，迄今为止，缺乏关于流行率的汇总数据。本荟萃分析的目的是评估强直性脊柱炎（AS）和nr-axSpA.Methods外周和关节外表现的患病率：我们进行了系统的文献检索，以确定出版物描述的患病率外周和关节外疾病的表现与AS和nr-axSpA患者。我们评估了偏倚风险和研究间异质性，并提取了数据。汇总患病率和患病率差异进行了calculated.Results：8项研究，包括2236例AS和1242与nr-axSpA患者被纳入：7项研究是纵向队列研究。AS（70.4%，95% CI 64.4，76.0%）中男性占优势，但nr-axSpA（46.8%，95% CI 41.7，51.9）中男性占优势，这与人类白细胞抗原（HLA）-B27的患病率无关。HLA-B27的患病率在AS（78.0%，95%CI 73.9，81.9%）和nr-axSpA（77.4%，95%CI 68. 9，84.9%））。关节炎的合并患病率（29.7%（95% CI 22.4，37.4%）vs 27.9%（95% CI 16.0，41.6%）），附着点炎（28.8%（95% CI 2.6，64.8）vs 35.4%（95% CI 6.1，71.2））。指炎（6.0%（95% CI 4.7，7.5%）vs 6.0%）（95% CI 1.9，12.0%）），银屑病（10.2%（95% CI 7.5，13.2%）vs 10.9%）（95% CI 9.1，13.0%）和炎症性肠病（4.1%（95% CI 2.3，6.5%）vs 6.4%（95% CI 3.6，9.7%））在AS和nr-axSpA中相似。葡萄膜炎的合并患病率在AS中（23.0%（95%CI 19.2，27.1%））高于nr-axSpA（15.9%（95%CI 11.8，20.4%））。结论：外周和关节外表现在AS和nr-axSpA中同样普遍，但葡萄膜炎在AS中的患病率略高。这些数据为nr-axSpA和AS中疾病表现的基本相同性质提供了证据。
Background: Peripheral disease (arthritis, enthesitis and dactylitis) and extra-articular disease (uveitis, psoriasis and inflammatory bowel disease) is common in ankylosing spondylitis (AS) and non-radiographic axial spondyloarthritis (nr-axSpA). So far, however, summary data on the prevalence are lacking. The objective of this meta-analysis was to assess the prevalence of peripheral and extra-articular manifestations in ankylosing spondylitis (AS) and nr-axSpA.Methods: We performed a systematic literature search to identify publications describing the prevalence of peripheral and extra-articular disease manifestations in patients with AS and nr-axSpA. We assessed the risk of bias and between-study heterogeneity, and extracted data. Pooled prevalence and prevalence differences were calculated.Results: Eight studies comprising 2236 patients with AS and 1242 with nr-axSpA were included: 7 of the studies were longitudinal cohort studies. There was male predominance in AS (70.4 %, 95 % CI 64.4, 76.0 %) but not in nr-axSpA (46.8 %, 95 % CI 41.7, 51.9), which was independent of the prevalence of human leukocyte antigen (HLA)-B27. The prevalence of HLA-B27 was similar in AS (78.0 % (95 % CI 73.9, 81.9 %) and nr-axSpA (77.4 %, 95 % CI 68. 9, 84.9 %)). The pooled prevalence of arthritis (29.7 % (95 % CI 22.4, 37.4 %) versus 27.9 % (95 % CI 16.0, 41.6 %)), enthesitis (28.8 % (95 % CI 2.6, 64.8) versus 35.4 % (95 % CI 6.1, 71.2)). dactylitis (6.0 % (95 % CI 4.7, 7.5 %) versus 6.0 % (95 % CI 1.9, 12.0 %)), psoriasis (10.2 % (95 % CI 7.5, 13.2 %) versus 10.9 % (95 % CI 9.1, 13.0 %)) and inflammatory bowel disease (4.1 % (95 % CI 2.3, 6.5 %) versus 6.4 % (95 % CI 3.6, 9.7 %)) were similar in AS and nr-axSpA. The pooled prevalence of uveitis was higher in AS (23.0 % (95 % CI 19.2, 27.1 %)) than in nr-axSpA (15.9 % (95 % CI 11.8, 20.4 %)).Conclusion: Peripheral and extra-articular manifestations are equally prevalent in AS and nr-axSpA, except for uveitis, which is slightly more prevalent in AS. These data provide evidence for the largely equal nature of disease manifestations in nr-axSpA and AS.