Accelerated maturation of white matter in young children with autism: A high b value DWI study
Accelerated maturation of white matter in young children with autism: A high b value DWI study
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DOI：
10.1016/j.neuroimage.2007.04.060
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发表时间：
2007-08-01
期刊：
影响因子：
5.7
通讯作者：
Sira, Liat Ben
中科院分区：
文献类型：
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作者：
Bashat, Dafna Ben;Kronfeld-Duenias, Vered;Sira, Liat Ben
这项工作的目的是研究白色物质成熟的自闭症幼儿在早期发展过程中增加大脑容量的报告，以及在这个关键的发展时期异常的神经生长模式和调节的论点。我们应用扩散张量成像（DTI）和高B值扩散加权成像（DWI）诊断为自闭症的幼儿和一个典型的发展（TD）对照组。在总体分析以及感兴趣区域（ROI）中测量分数各向异性（FA）、概率和位移。将自闭症儿童的个体数据点与从典型发育儿童获得的发育曲线进行比较。在总体分析以及几个脑区中检测到限制增加，反映在FA和概率沿着增加以及位移值降低。限制增加，提示白色物质的早期和加速异常成熟，在左半球更占主导地位，主要在额叶检测到。在枕叶中未检测到变化。这些结果支持先前的说法，异常的大脑过度生长的幼儿自闭症，并在以前的研究报告中，在青少年自闭症的限制扩散减少。(c)2007爱思唯尔公司All rights reserved.
The goal of this work was to study white matter maturation in young children with autism following previous reports of increased cerebral volume during early development, as well as arguments for abnormal neural growth patterns and regulation at this critical developmental period. We applied diffusion tensor imaging (DTI) and high b value diffusion-weighted imaging (DWI) to young children diagnosed with autism and to a typically developing (TD) control group. Fractional anisotropy (FA), probability and displacement were measured in overall analysis as well as in regions of interest (ROI). Individual data points of children with autism were compared to the developmental curves obtained from typically developing children. Increased restriction, reflected in significantly increased FA and probability along with reduced displacement values, was detected in overall analysis as well as in several brain regions. Increased restriction, suggesting an early and accelerated abnormal maturation of white matter, was more dominant in the left hemisphere and was mainly detected in the frontal lobe. No changes were detected in the occipital lobes. These results support previous claims of abnormal brain overgrowth in young children with autism and are in contrast to the decreased restricted diffusion reported in previous studies in adolescent with autism. (c) 2007 Elsevier Inc. All rights reserved.