Influence of prior pregnancies on disease course and cause of death in systemic sclerosis
Influence of prior pregnancies on disease course and cause of death in systemic sclerosis
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DOI：
10.1136/ard.61.4.346
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发表时间：
2002-04-01
影响因子：
27.4
通讯作者：
Jimenez, SA
中科院分区：
文献类型：
--
作者：
Artlett, CM;Rasheed, M;Jimenez, SA
背景资料：来自妊娠期间转移的胎儿或母体细胞的微嵌合体与系统性硬化症（SSc）的发病机制有关。目的：确定既往妊娠是否影响SSc患者的疾病进展和死亡原因。在托马斯杰斐逊大学随访的78例既往妊娠患者（PP）和33例从未妊娠的患者（NP）。结果：NP患者SSc的发病年龄为32.0岁，而有1次或2次妊娠史的患者为45.7岁（P < 0.05）。
Background: Microchimerism from fetal or maternal cells transferred during pregnancy has been implicated in the pathogenesis of systemic sclerosis (SSc).Objective: To determine whether a prior pregnancy influenced disease progression and cause of death in patients with SSc.Patients and methods: The patients comprised a retrospective study cohort of 111 women with SSc: 78 patients with prior pregnancies (PP) and 33 who were never pregnant (NP), followed up at Thomas Jefferson University. Differences in age at onset, disease subset, organ involvement, cause of death, and type of antinuclear autoantibodies were evaluated statistically, including regression analysis.Results: The age at onset of SSc in NP patients was 32.0 years compared with 45.7 years in patients with one or two prior pregnancies (p