Extra-cellular matrix in vascular networks
Extra-cellular matrix in vascular networks
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DOI：
10.1111/j.1365-2184.2004.00306.x
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发表时间：
2004-06-01
影响因子：
8.5
通讯作者：
Abraham, D
中科院分区：
文献类型：
--
作者：
Bou-Gharios, G;Ponticos, M;Abraham, D
血管网络是由内皮、装饰血管腔的单层细胞和间充质细胞（血管平滑肌、周细胞和成纤维细胞）的周围层组成的一系列连接的血管导管。除了提供结构支持外，间充质细胞对血管收缩性至关重要。细胞外基质是血管的主要成分，并提供了这些不同类型的细胞附着和嵌入的框架。血管细胞外基质的组成和组织主要由间充质细胞控制，并且还负责血管壁的机械性质，形成高度调节的结构蛋白的复杂网络。细胞外基质也在细胞粘附、分化和增殖中起核心作用。本文综述了血管的细胞和细胞外基质成分，特别强调I型胶原的调节和血管疾病的影响。
The vascular network is a series of linked conduits of blood vessels composed of the endothelium, a monolayer of cells that adorn the vessel lumen and surrounding layer(s) of mesenchymal cells (vascular smooth muscle, pericytes and fibroblasts). In addition to providing structural support, the mesenchymal cells are essential for vessel contractility. The extracellular matrix is a major constituent of blood vessels and provides a framework in which these various cell types are attached and embedded. The composition and organization of vascular extracellular matrix is primarily controlled by the mesenchymal cells, and is also responsible for the mechanical properties of the vessel wall, forming complex networks of structural proteins which are highly regulated. The extracellular matrix also plays a central role in cellular adhesion, differentiation and proliferation. This review examines the cellular and extracellular matrix components of vessels, with specific emphasis on the regulation of collagen type I and implications in vascular disease.