Optimization of in vivo high-resolution DTI of non-human primates on a 3T human scanner
Optimization of in vivo high-resolution DTI of non-human primates on a 3T human scanner
复制标题
DOI：
10.1016/j.ymeth.2009.06.008
复制
发表时间：
2010-03-01
期刊：
影响因子：
4.8
通讯作者：
Zhong, Jianhui
中科院分区：
文献类型：
--
作者：
Liu, Xiaoxu;Zhu, Tong;Zhong, Jianhui
磁共振（MR）扩散张量成像（DTI）已成为一种独特的技术，通过表征图像体素内水分子的扩散过程来揭示大脑的小解剖结构。结合纤维束成像技术，DTI可以进一步无创地显示脑内白色纤维和连接。非人类灵长类动物大脑研究为人类大脑探索提供了重要的补充手段，因为这两个物种在解剖学和功能上有着密切的相似性。因此，对体内非人灵长类动物DTI研究的兴趣越来越大。然而，需要解决几个技术挑战，以执行非人灵长类动物的大脑DTI和纤维束成像。我们已经建立了一个成像协议，连同一个后采集程序的高分辨率在体内非人灵长类动物DTI研究使用3T人体临床扫描仪。该程序采集的数据适用于精确的弥散张量定量和纤维束成像，并且可在可接受的扫描时间内访问。我们详细研究了空间分辨率和信噪比对扩散张量导出量和纤维束成像的影响。我们的研究结果应该是在体内实施非人灵长类动物DTI研究的一般效用。(C)2009 Elsevier Inc. All rights reserved.
Magnetic resonance (MR) diffusion tensor imaging (DTI) has emerged as 1 unique technique to reveal small anatomical structures of brain by characterizing the diffusion process of water molecules within an image voxel. Combined with fiber tractography techniques, DTI can be further used to reveal white matter fibers and connectivity in the brain non-invasively. The non-human primate brain Study provides important supplemental means for human brain exploration since the two species share close anatomical and functional similarities. There is therefore increasing interest in in vivo non-human primate DTI studies. However, several technical challenges need to be addressed to perform non-human primate brain DTI and fiber tractography. We have established an imaging protocol together with a post-acquisition procedure for high-resolution in vivo non-human primate DTI studies using a 3T human clinical scanner. Data acquired with this procedure is appropriate for accurate diffusion tensor quantification and fiber tractography, and is accessible within an acceptable scan time. We investigated in detail the effects of spatial resolution and SNR on diffusion tensor-derived quantities and fiber tractography. Our results should be of general utility for implementation of in vivo non-human primate DTI studies. (C) 2009 Elsevier Inc. All rights reserved.