Water homeostasis and vasopressin release during rodent and human gestation.
Water homeostasis and vasopressin release during rodent and human gestation.
复制标题
啮齿动物和人类妊娠期间的水稳态和加压素释放。
DOI：
10.1016/s0272-6386(87)80121-x
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Davison,JM
中科院分区：
文献类型：
--
作者：
Lindheimer,MD;Barron,WM;Dürr,J;Davison,JM
在人类和啮齿动物的妊娠期间，身体的滋补力都有所下降，表现为Posmof ~ 10 mosm/kg的下降。在人类中，口渴的渗透阈值的降低可能比精氨酸抗利尿激素（AVP）分泌阈值的降低早几个星期，而AVP的代谢清除率在妊娠晚期显着增加。这些渗透调节变化的原因尚不清楚，自1986年以来，我们一直无法将胎盘提取物、雌激素、黄体酮、催乳素、血管紧张素II和某些内啡肽与大鼠怀孕期间Posmobserved减少联系起来。妊娠期avp分泌关系也会发生变化。例如，Sprague-Dawley大鼠在妊娠期间改变了AVP的体积感应释放机制，使血管内体积的增加被认为是正常的。
Body tonicity decreases during both human and rodent gestation, manifested by a decrease in Posmof ~ 10 mosm/kg. In humans, the decrease in the osmotic threshold for thirst may precede decrements in the arginine vasopressin (AVP) secretory threshold by several weeks, whereas the metabolic clearance rate of AVP appears markedly increased in the third trimester. The cause of these osmoregulatory changes are unclear, since through 1986 we have been unable to implicate placental extracts, estrogens, progesterone, prolactin, angiotensin II, and certain endorphins in the decreased Posmobserved during rat pregnancy. Changes also occur in volume-AVP secretory relationships in pregnancy. For instance, the volume-sensing AVP release mechanisms are altered during gestation in Sprague-Dawley rats in such a way that the increased intravascular volume is recognized as normal.