Lack of a role of the duodenal microflora in pathogenesis of persistent diarrhea and diarrhea-related malabsorption in Peruvian children.
Lack of a role of the duodenal microflora in pathogenesis of persistent diarrhea and diarrhea-related malabsorption in Peruvian children.
复制标题
十二指肠微生物群在秘鲁儿童持续性腹泻和腹泻相关吸收不良的发病机制中缺乏作用。
DOI：
10.1097/00006454-199007000-00006
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
H. Smith
中科院分区：
文献类型：
--
作者：
M. Penny;P. Paredes;K. Brown;B. Laughan;H. Smith
虽然很少有腹泻发作持续时间超过14天，但这些发作尤其与生长发育迟缓和营养不良有关。我们通过比较89名持续性腹泻儿童、38名急性腹泻儿童和34名来自相同环境的无腹泻儿童的微生物区系，研究了十二指肠微生物区系在延长3-36个月大的秘鲁儿童腹泻中的作用。从所有吸入物中提取了93%的细菌，包括来自对照的94%。3组间细菌总数、十二指肠肠杆菌感染比例和厌氧菌比例均无显著差异，不支持急性期肠内细菌增殖延长腹泻的假说。当只比较18个月大的儿童时，持续性腹泻患者的厌氧菌培养频率高于对照组，但厌氧菌的存在与不良临床结果无关。尽管吸收不良，特别是脂溢症很常见，但在69名接受相同饮食的儿童中，细菌数量增加与粪便营养损失之间没有关联。在这个人群中，脂肪泻不能归因于细菌的过度生长。
Although few episodes of diarrhea last longer than 14 days these episodes are particularly associated with growth faltering and malnutrition. We have examined the role of the duodenal microflora in prolonging diarrhea in Peruvian children ages 3 to 36 months by comparing the microflora in 89 children with persistent diarrhea, 38 children with acute diarrhea and 34 diarrhea-free controls from the same environment. Bacteria were retrieved from 93% of all aspirates, including 94% of those from controls. There were no significant differences among the 3 groups with respect to total bacterial count, to the proportion of children with duodenal Enterobacteriaceae and to the proportion with anaerobes, lending no support to the hypothesis that proliferation of bacteria in the small intestine during the acute illness prolongs diarrhea. When only children older than 18 months were compared, anaerobes were cultured more frequently from those with persistent diarrhea than from controls, but the presence of anaerobes was not associated with adverse clinical outcome. Although malabsorption, especially steatorrhea, was common, there was no association between elevated bacterial counts and fecal loss of nutrients in 69 children who received the same diet. In this population steatorrhea could not be attributed to bacterial overgrowth.