Vitamin A in experimental herpetic keratitis.
Vitamin A in experimental herpetic keratitis.
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实验性疱疹性角膜炎中的维生素 A。
DOI：
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发表时间：
1981
期刊：
影响因子：
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通讯作者：
J. Oh
中科院分区：
文献类型：
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作者：
M. Starr;C. Dawson;O. Briones;J. Oh
研究了三种剂量水平的全身维生素A棕榈酸酯对皮质类固醇治疗家兔实验性单纯疱疹病毒（HSV）角膜炎的影响。高剂量的维生素A棕榈酸盐降低了疱疹性角膜炎的严重程度，但低剂量或中等剂量没有，而且没有维生素A治疗影响病毒的恢复。然而，在未感染的兔子和接受皮质类固醇治疗的单纯疱疹病毒感染的兔子中，维生素A治疗产生了显著的体重减轻。单独使用类固醇治疗可显著增加抗体对HSV的反应，但维生素A不能增强这种作用。对HSV角膜炎的轻微有益作用可归因于维生素A已知的促进上皮愈合的作用，而不是增强免疫力。为此，局部应用维生素A可能与全身作用一样有效，而且毒性要小得多。
Systemic vitamin A palmitate at three dosage levels was evaluated for its effect on experimental herpes simplex virus (HSV) keratitis in corticosteroid-treated rabbits. High-dose vitamin A palmitate reduced the severity of herpetic keratitis, but the low or moderate doses did not, and none of the vitamin A treatments affected virus recovery. Vitamin A treatment, however, produced substantial weight loss in uninfected rabbits and in corticosteroid-treated, HSV-infected rabbits. Steroid treatment alone significantly increased the antibody response to HSV, but this effect was not enhanced by vitamin A. The slight beneficial effect on HSV keratitis could be attributed to the known effect of vitamin A on promoting epithelial healing rather than an enhancement of immunity. For this purpose, local application of vitamin A may be just as effective and much less toxic than administration for systemic effect.