Beta carotene uptake into atherosclerotic plaque: enhanced staining and preferential ablation with the pulsed dye laser.
Beta carotene uptake into atherosclerotic plaque: enhanced staining and preferential ablation with the pulsed dye laser.
复制标题
动脉粥样硬化斑块吸收 β 胡萝卜素：使用脉冲染料激光增强染色和优先消融。
DOI：
10.1002/lsm.1900130202
复制
发表时间：
1993
影响因子：
2.4
通讯作者：
Wood,RF
中科院分区：
文献类型：
--
作者：
Mitchell,DC;Prince,MR;Frisoli,JK;Smith,RE;Wood,RF
动脉粥样硬化斑块的黄色是由于类胡萝卜素的存在，类胡萝卜素吸收430-530 nm之间的光，并解释了在480 nm处工作的脉冲染料激光对斑块的优先消融。本研究旨在检查β-胡萝卜素的组织摄取以及摄取对动脉斑块消融的影响。对42只动脉粥样硬化NZW家兔静脉注射β-胡萝卜素，剂量为40 mg/kg，每周两次，并在首次注射后1小时至28天内处死。在对照样本中未检测到β-胡萝卜素，但在β-胡萝卜素注射后的所有时间点，斑块中的β-胡萝卜素显著高于正常壁（P< 0.04 Mann Whitney U检验）。β-胡萝卜素治疗斑块的消融阈值显著低于未治疗斑块或正常动脉壁（P< 0.01，Fisher精确检验）。在该模型中，β-胡萝卜素优先被动脉斑块吸收，导致480 nm激光辐射吸收增加，组织消融增强。© 1993 Wiley利斯公司
The yellow color of atherosclerotic plaque is due to the presence of carotenoids, which absorb light between 430–530 nm and account for the preferential ablation of plaque by the pulsed dye laser operating at 480 nm. This study was designed to examine tissue uptake of β‐carotene and the effect of uptake on arterial plaque ablation. Forty‐two atherosclerotic NZW rabbits were given intravenous β‐carotene at a dose of 40 mg/kg, twice weekly and killed between 1 hour and 28 days after the initial injection. β‐carotene was not detected in control specimens but was significantly greater in plaque than in normal wall at all time points following β‐carotene injection (P< 0.04 Mann Whitney U test). The ablation threshold was significantly lower in β‐carotene treated plaque than in untreated plaque or normal arterial wall (P< 0.01, Fisher's exact test). In this model β‐carotene is preferentially taken up into arterial plaque, resulting in increased absorption of laser radiation at 480 nm and enhanced tissue ablation. © 1993 Wiley‐Liss, Inc.