Neuroanatomical Prediction of Anhedonia in Adolescents
Neuroanatomical Prediction of Anhedonia in Adolescents
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DOI：
10.1038/npp.2017.28
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发表时间：
2017-09-01
影响因子：
7.6
通讯作者：
Pizzagalli, Diego A.
中科院分区：
文献类型：
--
作者：
Auerbach, Randy P.;Pisoni, Angela;Pizzagalli, Diego A.
快感缺失是一种跨诊断风险因素，与精神疾病发作、治疗无反应和自杀行为有关。先前对成人的横断面研究表明，快感缺乏与背侧纹状体体积减少有关，但尚不清楚这种关系是否延伸到青少年，以及纹状体体积减少是否前瞻性地预测快感缺乏。为了解决这些差距，当前的研究调查了纹状体体积是否可以预测青少年快感缺失的严重程度。在基线时，12-14 岁的健康女性青少年 (n = 50) 完成了临床评估，并在 3 Tesla MR 扫描仪上获取结构 MRI 数据。在扫描仪中，参与者还完成了同伴反馈任务，获得了同伴“接受”或“拒绝”后的主观评分。在三个月的随访中，参与者提供了对快感缺失、抑郁和焦虑症状的自我报告评估。出现了三个主要发现。首先，在横断面分析中，右伏核体积与快感缺乏严重程度呈负相关。其次，双侧壳核体积的减少可以前瞻性地预测快感缺乏的严重程度，同时控制基线快感缺乏、抑郁和焦虑症状。第三，对同伴接受的主观反应迟钝（即对积极反馈的中立反应），而不是对同伴拒绝的更消极的主观反应，导致了快感缺失的严重程度，但仅限于壳核体积较小的青少年。总的来说，这些结果表明，与奖励处理密切相关的纹状体区域体积较小与健康女性青少年当前和未来的快感缺乏症状有关。这些解剖学特征可能导致快感缺失的脆弱性，因此可以帮助早期识别精神疾病高风险个体。
Anhedonia is a transdiagnostic risk factor implicated in mental illness onset, treatment non-response, and suicidal behaviors. Prior cross-sectional research in adults has shown that anhedonia is associated with reduced dorsal striatal volume, but it is unknown whether this relationship extends to adolescents and whether reduced striatal volume prospectively predicts anhedonia. To address these gaps, the current study investigated whether striatal volume predicted anhedonia severity in adolescents. At baseline, healthy female adolescents aged 12-14 years (n = 50) completed a clinical assessment, and structural MRI data were acquired on a 3 Tesla MR scanner. While in the scanner, participants also completed a peer feedback task where subjective ratings following peer 'acceptance' or 'rejection' were obtained. At the three-month follow-up, participants provided self-report assessments of anhedonia, depression, and anxiety symptoms. Three main findings emerged. First, in cross-sectional analyses, right nucleus accumbens volume was inversely related to anhedonia severity. Second, reduced bilateral putamen volume prospectively predicted anhedonia severity while controlling for baseline anhedonia, depression, and anxiety symptoms. Third, a blunted subjective response to peer acceptance (ie, neutral response to positive feedback), but not a more negative subjective response to peer rejection, contributed to anhedonia severity, but only among youth with smaller putamen volume. Collectively, these results suggest that smaller volume in striatal regions critically implicated in reward processing is associated with current and future anhedonic symptoms among healthy female youth. These anatomical features may confer vulnerability to anhedonia and thus, may inform early identification of individuals at high risk for mental illness.