Endocannabinoid signaling, glucocorticoid-mediated negative feedback, and regulation of the hypothalamic-pituitary-adrenal axis.
Endocannabinoid signaling, glucocorticoid-mediated negative feedback, and regulation of the hypothalamic-pituitary-adrenal axis.
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DOI：
10.1016/j.neuroscience.2011.12.030
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发表时间：
2012-03-01
期刊：
影响因子：
3.3
通讯作者：
Tasker, J. G.
中科院分区：
文献类型：
--
作者：
Hill, M. N.;Tasker, J. G.
下丘脑-垂体-肾上腺（HPA）轴调节基础条件下和应激反应中糖皮质激素的流出。在过去的十年中，大量的证据表明，内源性大麻素系统参与了应激反应的中枢调控;然而，内源性大麻素信号传导在HPA轴调节阶段或介导这种调节的神经作用部位中发挥的具体作用，直到最近才被绘制出来。这篇综述的目的是崩溃的知识，内源性大麻素系统在HPA轴的调节中的作用的当前状态放在一起的工作模型内源性大麻素如何和在哪里在大脑中发挥作用，以调节HPA轴的流出。具体而言，我们讨论了内源性大麻素系统在基础条件下HPA轴的调节中的作用，急性应激和糖皮质激素介导的负反馈的激活。有趣的是，在HPA轴调节的每个阶段中，内源性大麻素系统的作用似乎有一些解剖学特异性，以及花生四烯酸和2-花生四烯酸甘油在这些阶段中的不同作用。最后，目前的信息水平表明，内源性大麻素信号通过前额叶皮层、杏仁核和下丘脑内的协调行动来抑制HPA轴活动。
The hypothalamic-pituitary-adrenal (HPA) axis regulates the outflow of glucocorticoid hormones under basal conditions and in response to stress. Within the last decade, a large body of evidence has mounted indicating that the endocannabinoid system is involved in the central regulation of the stress response; however, the specific role endocannabinoid signalling plays in phases of HPA axis regulation, or the neural sites of action mediating this regulation, was not mapped out until recently. This review aims to collapse the current state of knowledge regarding the role of the endocannabinoid system in the regulation of the HPA axis to put together a working model of how and where endocannabinoids act within the brain to regulate outflow of the HPA axis. Specifically, we discuss the role of the endocannabinoid system in the regulation of the HPA axis under basal conditions, activation in response to acute stress and glucocorticoid-mediated negative feedback. Interestingly, there appears to be some anatomical specificity to the role of the endocannabinoid system in each phase of HPA axis regulation, as well as distinct roles of both anandamide and 2-arachidonoylglycerol in these phases. Ultimately, the current level of information indicates that endocannabinoid signalling acts to suppress HPA axis activity through concerted actions within the prefrontal cortex, amygdala and hypothalamus.
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