The Effects of Flaxseed Oil on Cadmium-Induced Oxidative Stress in Rats
The Effects of Flaxseed Oil on Cadmium-Induced Oxidative Stress in Rats
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DOI：
10.1007/s12011-013-9804-7
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发表时间：
2013-09
影响因子：
3.9
通讯作者：
S. Karaca;G. Eraslan
中科院分区：
文献类型：
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作者：
S. Karaca;G. Eraslan
本研究探讨了亚麻籽油对镉中毒大鼠氧化-抗氧化系统的影响。将48只雄性Wistar白化病大鼠分为4组（组1）。对照组不进行任何处理。另一方面，第2、3和4组分别以0.1 ml/大鼠/天（约500 mg/kg bw）的剂量经胃管饲给予亚麻籽油、50 ppm镉（约40 mg/kg bw）的自由饮用水以及0.1 ml/大鼠/天亚麻籽油加50 ppm镉，持续30天。研究结束时，测量了血液和组织（肝脏、肺、肾脏、脑、心脏和睾丸）样本中的丙二醛和一氧化氮水平以及过氧化氢酶、超氧化物歧化酶和谷胱甘肽过氧化物酶活性。而丙二醛和一氧化氮水平增加组给予镉与对照组相比，在同一时间，有一些显着的变化，抗氧化酶的活性。观察到这些变化，与对照组相比有减少或增加的趋势。与仅接受镉的组相比，给予亚麻籽油加镉的组的参数有积极的变化，换句话说，观察到接近对照组的值。因此，镉暴露引起的氧化损伤红细胞和器官在不同的速度，而亚麻籽油降低镉诱导的脂质过氧化的严重程度。因此，可以得出结论，亚麻籽油可用作治疗剂或食品添加剂，用于预防镉中毒的化合物。
In the present study, the effects of flaxseed oil on the oxidant–antioxidant system in cadmium intoxication were investigated in rats. Forty-eight male Wistar albino rats were divided into four equal groups (group 1). No treatment was applied to the control group. On the other hand, groups 2, 3, and 4 were administered with 0.1 ml/rat/day (∼500 mg/kg bw) flaxseed oil by gavage into the stomach, 50 ppm of cadmium (∼4 mg/kg bw) in ad libitum drinking water, and 0.1 ml/rat/day flaxseed oil plus 50 ppm of cadmium, respectively, for 30 days. At the end of the study, malondialdehyde and nitric oxide levels and catalase, superoxide dismutase, and glutathione peroxidase activities were measured in blood and tissue (liver, lung, kidney, brain, heart, and testes) samples. While malondialdehyde and nitric oxide levels increased in the group given cadmium compared to the control group; in the meantime, there were some significant changes in antioxidant enzyme activities. These changes were observed, the trends of decrease or increase compared to the control group. There were positive changes in parameters of the group given with flaxseed oil plus cadmium compared to the group receiving cadmium alone, in other words, values were seen coming close to control group. As a result, cadmium exposure caused oxidative damage to erythrocytes and organs at varying rates, while flaxseed oil reduced the severity of cadmium-induced lipid peroxidation. Therefore, it was concluded that flaxseed oil can be used among compounds as a therapeutic agent or food additive for prophylaxis in cadmium intoxication.