CpG DNA overcomes hyporesponsiveness to hepatitis B vaccine in orangutans
CpG DNA overcomes hyporesponsiveness to hepatitis B vaccine in orangutans
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DOI：
10.1016/s0264-410x(99)00443-0
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发表时间：
2000-03-17
期刊：
影响因子：
5.5
通讯作者：
Sajuthi, D
中科院分区：
文献类型：
--
作者：
Davis, HL;Suparto, I;Sajuthi, D
Oligonucleotides containing immunostimulatory CpG motifs (CpG ODN) have been shown to be potent Th1-type adjuvants far augmenting antigen-specific responses in mice against hepatitis B surface antigen (HBsAg), The hepatitis B virus (HBV) infects only humans and great apes and瓦德黑猩猩和猩猩中似乎存在猩猩中HBV的爆发被修复以重新引入丛林，导致了几只动物的死亡。预防性疫苗接种计划表明，与先前在人类和黑猩猩中获得的结果相比，猩猩对当前商业疫苗的反应非常低。在乙型肝炎中添加CpG ODN疫苗可大大提高了血清转化率和针对HBSAG（抗HBS）的抗体的滴度。这是第一个：大猿中CpG DNA的演示，结果对人类对HBV和其他疾病的疫苗接种具有重要意义。 （c）2000 Elsevier Science Ltd.保留所有权利。
Oligonucleotides containing immunostimulatory CpG motifs (CpG ODN) have been shown to be potent Th1-type adjuvants far augmenting antigen-specific responses in mice against hepatitis B surface antigen (HBsAg), The hepatitis B virus (HBV) infects only humans and great apes and appears to exist among wad chimpanzees and orangutans, An outbreak of HBV among orangutans being rehabilitated for re-introduction to the jungle caused the death of several animals. A prophylactic vaccination program revealed that orangutans are quite hypo-responsive to a current commercial vaccine compared to results obtained previously in humans and chimpanzees. Addition of CpG ODN to hepatitis B vaccine greatly increased the seroconversion rate and the titers of antibody against HBsAg (anti-HBs). This is the first: demonstration of CpG DNA in a great ape and the results have important implications for the vaccination of humans against HBV and other diseases. (C) 2000 Elsevier Science Ltd. All rights reserved.