CONGENITAL CARDIOVASCULAR MALFORMATIONS IN TWINS AND TRIPLETS FROM A POPULATION-BASED STUDY
CONGENITAL CARDIOVASCULAR MALFORMATIONS IN TWINS AND TRIPLETS FROM A POPULATION-BASED STUDY
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DOI：
10.1001/archpedi.1989.02150240083023
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发表时间：
1989-12-01
影响因子：
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通讯作者：
FERENCZ, C
中科院分区：
文献类型：
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作者：
BERG, KA;ASTEMBORSKI, JA;FERENCZ, C
先天性心血管畸形的巴尔的摩 - 华盛顿婴儿研究的数据允许对62个双胞胎和3个三胞胎和2303例Singleton病例的先天性心血管畸形进行详细分析。对照组的概率样本（n = 2793）包括43个双胞胎。多个出生的病例患病率为1000个中的28个，而对照组中的1000例患病率为1000（.CHI.2 = 5.7）。案例双胞胎中的女孩比案例单例和对照组中的女孩多（.chi.2 = 9.0）。 在双胞胎的情况下，单子合格比对照组的频率不高。循环缺陷发生在4个单卵双胞胎对中，而仅1个双卵双胞胎对。双胞胎过程本身可能与其中一些婴儿（尤其是循环缺陷的人）中的先天性心血管畸形的发展有关，但在65对中的4对中的缺陷类型的一致性暗示了遗传因素在某些形式的先天性心血管畸形的确定中暗示。
Data from the Baltimore-Washington Infant Study of congenital cardiovascular malformations permitted detailed analysis of congenital cardiovascular malformations in 62 twins and 3 triplets and 2303 singleton cases. A probability sample of controls (n = 2793) included 43 twins. The case prevalence of multiple births was 28 of 1000, compared with a 15 of 1000 prevalence among controls (.chi.2 = 5.7). There were more girls among case twins than among case singletons and controls (.chi.2 = 9.0). Monozygosity was no more frequent in case twins than in controls. Looping defects occurred in 4 monozygotic twin pairs compared with only 1 dizygotic twin pair. The twinning process itself may be implicated in the development of congenital cardiovascular malformations in some of these infants, especially those with looping defects, but concordance of types of defects in 4 of 65 pairs implicates genetic factors in the determination of some forms of congenital cardiovascular malformations.