Effects of baicalein on leukotriene C4 biosynthesis in human lymphocytes
Effects of baicalein on leukotriene C4 biosynthesis in human lymphocytes
复制标题
黄芩素对人淋巴细胞白三烯C4生物合成的影响
DOI：
10.1002/ptr.2650010111
复制
发表时间：
1987
影响因子：
7.2
通讯作者：
S. Arichi
中科院分区：
文献类型：
--
作者：
Y. Kimura;H. Okuda;S. Arichi
研究了黄岑素（5，6，7-三羟基黄酮）对人淋巴细胞钙离子载体A23187生物合成白三烯C4（LTC 4）的影响。黄芩素抑制人淋巴细胞中钙离子载体诱导的LTC 4生物合成。LTC 4形成的50%抑制（IC 50）所需的黄芩素浓度为4.3 × 10−7 M。
Studies were made on the effects of baicalein (5,6,7‐trihydroxyflavone) on leukotriene C4 (LTC4) biosynthesis by calcium ionophore A 23187 in human lymphocytes. Baicalein inhibited calcium ionophore‐induced LTC4 biosynthesis in human lymphocytes. The concentration of baicalein required for 50% inhibition (IC50) of LTC4 formation was 4.3 × 10−7 M.