Polyglycine II Nanosheets: Supramolecular Antivirals?
Polyglycine II Nanosheets: Supramolecular Antivirals?
复制标题
聚甘氨酸 II 纳米片：超分子抗病毒药物？
作者：
A. Tuzikov;A. Chinarev;A. Gambaryan;V. Oleinikov;D. Klinov;Nadezhda B. Matsko;V. A. Kadykov;M. Ermishov;Il'ya V. Demin;Victor V. Demin;Phillip D. Rye;N. Bovin
四触角肽[甘氨酸-NHCH 2]4C可以通过分子间氢键自组装形成稳定的非共价结构。寡肽链组装成聚甘氨酸II，产生亚微米尺寸的平坦的单分子厚的片。α-N-乙酰神经氨酸（Neu 5Ac α）与末端甘氨酸残基的连接产生了水溶性组装糖肽，其能够多价结合流感病毒，并比Neu 5Ac α的单体糖苷更有效地抑制病毒与细胞的粘附103倍。还证明了另一种基于病毒促进的糖肽组装的抗病毒策略。因此，自组装原理为多价抗病毒药物的设计提供了新的视角。
Tetraantennary peptides [glycinen‐NHCH2]4C can form stable noncovalent structures by self‐assembly through intermolecular hydrogen bonding. The oligopeptide chains assemble as polyglycine II to yield submicron‐sized, flat, one‐molecule‐thick sheets. Attachment of α‐N‐acetylneuraminic acid (Neu5Acα) to the terminal glycine residues gives rise to water‐soluble assembled glycopeptides that are able to bind influenza virus multivalently and inhibit adhesion of the virus to cells 103‐fold more effectively than a monomeric glycoside of Neu5Acα. Another antiviral strategy based on virus‐promoted assembly of the glycopeptides was also demonstrated. Consequently, the self‐assembly principle offers new perspectives on the design of multivalent antivirals.
IgG3 抗链球菌 A 组碳水化合物 (GAC) 抗体与链球菌 A 组疫苗的相互作用：增强和抑制抗 GAC、抗同种型和抗独特型抗体的作用。
DOI：
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发表时间：
1987
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
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作者：
Greenspan,NS;Monafo,WJ;Davie,JM
通讯作者：
Davie,JM